Does exposure to inflammatory particles modify the pattern of anion in exhaled breath condensate?

Exposure to environmental and occupational particulate matter (PM) induces health effects on the
cardio-pulmonary system. In addition, associations between exposure to PM and metabolic syndromes
like diabetes mellitus or obesity are now emerging in the literature. Collection of exhaled breath
condensate (EBC) is an appealing non-invasive technique to sample pulmonary fluids. This
hypothesis-generating study aims to (1) validate an ion chromatography method allowing the robust
determination of different metabolism-related molecules (lactate, formate, acetate, propionate,
butyrate, pyruvate, nitrite, nitrate) in EBC; (2) apply this method to EBC samples collected from
workers exposed to quartz (a known inflammatory particle), to soapstone (a less inflammatory
particle than quartz), as well as to controls. A multi-compound standard solution was used to
determine the linearity range, detection limit, repeatability and bias from spiked EBC. The
biological samples were injected withou...

Source: Journal of Breath Research - February 13, 2020 Category: Respiratory Medicine Authors: J-J Sauvain, J-L Edm é, P Wild, G Suarez, O M P A Bezerra, A Talvani, E Algranti, A P S Carneiro, N Chérot-Kornobis, A Sobaszek and S Hulo Source Type: research