Gut microbiota, endotoxemia, inflammation and oxidative stress in heart failure, lvad and trasplant patients

Gut microbial imbalance may contribute to endotoxemia, inflammation and oxidative stress in heart failure (HF). Changes occurring in the intestinal microbiota and inflammatory/oxidative milieu during HF progression and following left ventricular assist device (LVAD) or heart transplantation (HT) are unknown. We aimed to investigate variation in gut microbiota and circulating biomarkers of endotoxemia, inflammation and oxidative stress in patients with HF (New York Heart Association (NYHA) class I-IV), LVAD and HT.

Source: The Journal of Heart and Lung Transplantation - February 12, 2020 Category: Transplant Surgery Authors: Melana Yuzefpolskaya, Bruno Bohn, Mojdeh Nasiri, Amelia M. Zuver, Drew D Onat, Eugene A. Royzman, Joseph Nwokocha, Melissa Mabasa, Alberto Pinsino, Danielle Brunjes, Antonia Gaudig, Autumn Clemons, Pauline Trinh, Stephania Stump, Marla J. Giddins, Veli K. Tags: Original Clinical Science Source Type: research