Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and early major beta-cell function defects: a cross-sectional and longitudinal analysis of the relationship between insulin sensitivity and cardiovascular risk (RISC) study cohort

Uncertainty still exists on the earliest beta-cell defects at the bases of the type 2 diabetes. We assume that this depends on the inaccurate distinction between fasting and post-load glucose homeostasis and aim at providing a description of major beta-cell functions across the full physiologic spectrum of each condition.

Source: Metabolism - Clinical and Experimental - February 12, 2020 Category: Biomedical Science Authors: Alessandro Mengozzi, Domenico Tric ò, Lorenzo Nesti, John Petrie, Kurt Højlund, Asimina Mitrakou, Michael Krebs, Andrea Mari, Andrea Natali, RISC investigators Source Type: research