Platelet Glutamate Uptake and Th1 cells inversely correlate in relapsing/remitting and in progressive multiple sclerosis

Conclusions: Interestingly, as shown in the CNS, a relationship between clinical, inflammatory MS features and glutamate clearance can be also assessed in platelets. Moreover, glutamate uptake activity might be an useful biomarker to characterize patients with benign prognosis.Graphical abstract
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Publication date: Available online 31 March 2020Source: Neurología (English Edition)Author(s): L.A. Rodríguez de Antonio, I. García Castañón, M.J. Aguilar-Amat Prior, I. Puertas, I. González Suárez, C. Oreja Guevara
Source: Neurologia - Category: Neurology Source Type: research
Publication date: Available online 31 March 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Razieh Amini, Sajad karampoor, Hamid Zahednasab, Hossein Keyvani, Masoud Gheiasian, Farid Azizi Jalilian
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
Source: Patient Preference and Adherence - Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
ZEPOSIA is a drug used for the treatment of adults with relapsing forms of multiple sclerosis (RMS) including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Publication date: Available online 1 April 2020Source: Redox BiologyAuthor(s): Zeina El Ali, Anthony Ollivier, Sylvie Manin, Michael Rivard, Roberto Motterlini, Roberta Foresti
Source: Redox Biology - Category: Biology Source Type: research
AbstractPurposeCannabis has been used for thousands of years in many cultures for the treatment of several ailments including pain. The benefits of cannabis are mediated largely by cannabinoids, the most prominent of which are tetrahydrocannabinol (THC) and cannabidiol (CBD). As such, THC and/or CBD have been investigated in clinical studies for the treatment of many conditions including neuropathic pain and acute or chronic inflammation. While a plethora of studies have examined the biochemical effects of purified THC and/or CBD, only a few have focused on the effects of full-spectrum cannabis plant extract. Accordingly, ...
Source: Inflammation Research - Category: Research Source Type: research
AbstractBy the discovery of an antibody to aquaporin 4 (AQP4), the clinical and radiological findings of neuromyelitis optica (NMO) such as diffuse cerebral or longitudinally extended spinal cord lesions had been clarified as distinct features from multiple sclerosis (MS). Pathological studies in NMO demonstrated loss of immunoreactivity to AQP4 and glial fibrillary acidic protein but a relative preservation of myelin basic protein, especially at the lesions with perivascular deposition of immunoglobulins and complements, suggesting autoimmune disease against astrocytes. In recent years, the antibody against myelin oligode...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research
We examined the oligodendrocyte‐mediated demyelination and axonal injury. To address this issue, we established a new scanning electron microscopy analysis to observe ultrastructural myelin morphology. In addition, we focused on kallik rein 6, a serine protease, secreted by oligodendrocytes in the central nervous system and proposed a new molecular mechanism of kallikrein 6‐mediated demyelination. In this article, we discuss the pathological roles of oligodendrocytes in mouse models of EAE. We also highlight recent findings of abnormal myelin formation and axonal injury in EAE.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research
AbstractMyelin oligodendrocyte glycoprotein (MOG) is a minor myelin protein localized at the outermost layer of the myelin sheath. Cell ‐based assays to detect conformation‐sensitive MOG‐immunoglobulin G (IgG) have identified a unique group of patients with optic neuritis, acute/multiphasic disseminated encephalomyelitis, encephalitides (brainstem and cerebral cortical), myelitis and aquaporin‐4 IgG‐negative neuromyelitis optica spectrum disorders. MOG‐IgG‐associated disease affects both children and adults, and the female : male ratio is almost 1:1. Cerebrospinal fluid (CSF) examination shows ...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research
AbstractConnexins, which comprise gap junctions (GJs) via homotypic/heterotypic oligomerization, act as channels to connect opposing cells, mainly in solid organs such as the skin, liver, heart, and central/peripheral nervous system. Connexins are synthesized in the endoplasmic reticulum, assembled in the Golgi apparatus as hexamers, and inserted into the cell membrane as hemichannels. These hemichannels are closed under normal conditions until they combine to form clusters and connect to neighboring cells via GJs in a head ‐to‐head configuration. Opening of hemichannels, which depends on the intra‐ or extracellular ...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research
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