A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease [Immunology and Inflammation]
The highly homologous human leukocyte antigen (HLA)-DQ2 molecules, HLA-DQ2.5 and HLA-DQ2.2, are implicated in the pathogenesis of celiac disease (CeD) by presenting gluten peptides to CD4+ T cells. However, while HLA-DQ2.5 is strongly associated with disease, HLA-DQ2.2 is not, and the molecular basis underpinning this differential disease association is unresolved....
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Yi Tian Ting, Shiva Dahal-Koirala, Hui Shi Keshia Kim, Shuo-Wang Qiao, Ralf S. Neumann, Knut E. A. Lundin, Jan Petersen, Hugh H. Reid, Ludvig M. Sollid, Jamie Rossjohn Tags: Biological Sciences Source Type: research
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