Congestive heart failure in rats is associated with increased collecting duct vasopressin sensitivity and vasopressin type 2-receptor re-externalization.
Congestive heart failure in rats is associated with increased collecting duct vasopressin sensitivity and vasopressin type 2-receptor re-externalization. Am J Physiol Renal Physiol. 2013 Oct 2; Authors: Brønd L, Müllertz KM, Torp M, Nielsen J, Græbe M, Hadrup N, Nielsen S, Christensen S, Jonassen TE Abstract A number of studies have shown that rats with congestive heart failure (CHF) have increased protein levels of the vasopressin-regulated water channel AQP2 even during conditions with unchanged circulating levels of vasopressin (AVP), suggesting an increase in the sensitivity of the AVP type-2 (V2) receptor in experimental CHF. The present study was aimed at investigating AVP signaling in rats with moderate CHF (left ventricular end diastolic pressure>10 mmHg; normal plasma AVP levels) induced by ligation of the left anterior descending coronary artery. Sham-operated rats were used as controls. Western blotting analyses revealed an increased abundance of AQP2 in renal cortex (+ 33±9 % of Sham; p
Authors: Das AK, Kalra S, Tiwaskar M, Bajaj S, Seshadri K, Chowdhury S, Sahay R, Indurkar S, Unnikrishnan AG, Phadke U, Pareek A, Purkait I Abstract Diabetes is a major public health emergency of the 21st century. Results of the Indian Council of Medical Research-INdia DIABetes (ICMR-INDIAB) study have found prevalence of diabetes and prediabetes in India to be as high as 7.3% and 10.3%, respectively with nation-wide projection of 77.2 million people with prediabetes and 69.2 million with diabetes. It is well established that insulin resistance (IR) and islet β-cell failure are the two major features of T2D Mu...
ConclusionThis prospective clinical trial will prove if withholding ACEIs/ARBs will prevent AKI in ADHF. It will help us understand the complex interactions between the heart and kidney, and delineate the best treatment strategy for ADHF. Holding ACEIs/ARBs might help preserve renal function, and decrease hospital LOS, readmission rates, and cost of care in ADHF.RegistrationClinicalTrials.gov identifier: NCT03695120.
ConclusionsHigher post-operative sST2 and gal-3 values were associated with increased incidence of cardiovascular event or mortality. These two biomarkers should be further studied for potential clinical utility for patients undergoing cardiac surgery.Graphical abstract
Vitamin D deficiency (25(OH)D) is a common finding in patients with congestive heart failure (HF) . Vitamin D might play a role in the pathogenesis of HF [1 –4], with mechanisms for this possibly including effects on the renin–angiotensin system, insulin secretion and sensitivity, protection against angiogenesis and reduction of the pro-inflammatory response in HF [5–7]. However, a recent vitamin D supplementation trial did not find a beneficial e ffect on parameters of renin-angiotensin system in patient with advance HF .
Conclusions. In conclusion, CCI or its individual components measuring the impact of comorbidities on overall mortality does not provide any significant value compared to GRACE-score during up to 2 years of follow-up. PMID: 31775530 [PubMed - as supplied by publisher]
CONCLUSION: 'AVNRT of the sick' has not been previously described in the medical literature, to our knowledge. It can be successfully treated with medications and the chance of recurrence after resolution of the acute illness is small. PMID: 31802764 [PubMed - in process]
CONCLUSION: Current evidence implicates a possible association between PEI and malnutrition in patients with CHF. Chronic pancreatic tissue hypoxic injury driven by prolonged splanchnic hypoperfusion is likely to contribute to malnutrition and cachexia in patients with CHF. On the other hand, CP and PEI seem to be an independent risk factor associated with an increased risk of cardiovascular events. PMID: 31802835 [PubMed - in process]
AbstractPurpose of ReviewThiazolidinediones (TZDs) are the only pharmacologic agents that specifically treat insulin resistance. The beneficial effects of TZDs on the cardiovascular risk factors associated with insulin resistance have been well documented. TZD use has been limited because of concern about safety issues and side effects.Recent FindingsRecent studies indicate that cardiovascular toxicity with rosiglitazone and increase in bladder cancer with pioglitazone are no longer significant issues. There are new data which show that pioglitazone treatment reduces myocardial infarctions and ischemic strokes. New data co...
Publication date: Available online 26 November 2019Source: Redox BiologyAuthor(s): Balaraman KalyanaramanAbstractDoxorubicin (DOX), or Adriamycin, an anthracycline antibiotic discovered serendipitously as a chemotherapeutic drug several decades ago, is still one of the most effective drugs for treating various adult and pediatric cancers (breast cancer, Hodgkin's disease, lymphoblastic leukemia). However, one of the major side effects of the continuous use of DOX is dose-dependent, long-term, and potentially lethal cardiovascular toxicity (congestive heart failure and cardiomyopathy) in cancer survivors many years after ce...
Entrectinib (Rozlytrek) has been approved by the Food and Drug Administration to treat adolescent and adult patients whose solid tumor cancers are related to a specific genetic defect known as neurotrophic tyrosine receptor kinase gene fusion, and for whom there are no effective treatments.Several warnings and precautions are listed on entrectinib's labeling, including congestive heart failure, central nervous system effects, skeletal fractures, hepatotoxicity, hyperuricemia, QT interval prolongation, vision disorders, and embryo–fetal toxicity.