Dexmedetomidine alleviates cisplatin ‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the α2AR/PI3K/AKT pathway.

In conclusion, Dex may alleviate CP‑induced AKI by attenuating ERS‑induced apoptosis, at least in part, via the α2AR/PI3K/AKT signaling pathway. PMID: 32016445 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32016445?dopt=Abstract

Source: Molecular Medicine Reports - February 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research