Bacteria and cancer: Different sides of the same coin

Publication date: Available online 4 February 2020Source: Life SciencesAuthor(s): Ghazaleh Laliani, Shokufeh Ghasemian Sorboni, Roya Lari, Atieh Yaghoubi, Saman Soleimanpour, Majid Khazaee, Seyed Mahdi Hasanian, Amir AvanAbstractConventional cancer therapies such as chemotherapy, radiation therapy, and immunotherapy due to the complexity of cancer have been unsuccessful in the complete eradication of tumor cells. Thus, there is a need for new therapeutic strategies toward cancer. Recently, the therapeutic role of bacteria in different fields of medicine and pharmaceutical research has attracted attention in recent decades. Although several bacteria are notorious as cancer-causing agents, recent research revealed intriguing results suggesting the bacterial potential in cancer therapy. Thus, bacterial cancer therapy is an alternative anticancer approach that has promising results on tumor cells in-vivo. Moreover, with the aid of genetic engineering, some natural or genetically modified bacterial strains can directly target hypoxic regions of tumors and secrete therapeutic molecules leading to cancer cell death. Additionally, stimulation of immune cells by bacteria, bacterial cancer DNA vaccine and antitumor bacterial metabolites are other therapeutic applications of bacteria in cancer therapy. The present study is a comprehensive review of different aspects of bacterial cancer therapy alone and in combination with conventional methods, for improving cancer therapy.Graphical abs...
Source: Life Sciences - Category: Biology Source Type: research

Related Links:

Most women who are notified by mail that they have a high risk of breast cancer are unlikely to do anything about it, a small study suggests.Reuters Health Information
Source: Medscape Radiology Headlines - Category: Radiology Tags: Hematology-Oncology News Source Type: news
ConclusionsOur study reveals the need for targeted patient ‐education about the benefits and limitations of follow‐up. In order to meet increasing costs of cancer care, individualized follow‐up procedures adjusted to risk of recurrence and late‐effects in cervical cancer survivors are warranted.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Radiation therapy vendor Varian Medical Systems has added new artificial intelligence...Read more on AuntMinnie.comRelated Reading: Varian gets FDA nod for Ethos adaptive therapy unit Varian posts strong Q1 sales growth as profit slips Varian installs systems in Africa, U.S. Varian awarded Mich. cancer software contract Varian posts continued revenue gains in Q4, fiscal 2019
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
AbstractNeuropathic pain (NeP) is an intractable pain caused by a lesion or disease of the somatosensory nervous system. NeP is often challenging to manage because most of the mechanisms remain to be elucidated. Recent investigations in the field of autoimmune neurology have demonstrated that specific autoantibodies against antigens in the somatosensory pathway can cause NeP. Detection of pathogenic autoantibodies in NeP adds to the understanding of the mechanism of pain, which might aid in the development of novel immunotherapies. Therefore, it is necessary to explore novel NeP ‐related autoantibodies to improve the man...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research
We’re tackling a few urgent questions from parents in this time of coronavirus and COVID-19. Are you wondering if babies and children should continue to have vaccines on schedule? Thinking about how to manage regular medical appointments, and which situations require in-person visits to a pediatric practice? Read on. Should parents take babies for initial vaccines right now? What about toddlers and older children who are due for vaccines? The answer to this question is going to depend on many factors, including what your doctor’s office is offering. As with all health care decisions, it comes down to weighing r...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Children's Health Health care Parenting Vaccines Source Type: blogs
Publication date: Available online 30 March 2020Source: Journal of EthnopharmacologyAuthor(s): Zu-Jun Que, Bin Luo, Chen-Tong Wang, Fang-Fang Qian, Yi Jiang, Yan Li, Xiang-Hui Han, He-Gen Li, Jia-Xiang Liu, Jian-Hui Tian
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 30 March 2020Source: International Journal of PharmaceuticsAuthor(s): Afshin Nikkhoo, Narges Rostami, Shohreh Farhadi, Maryam Esmaily, Sadaf Moghadaszadeh Ardebili, Fatemeh Atyabi, Masoumeh Baghaei, Navideh Haghnavaz, Mehdi Yousefi, Mohammad Reza Aliparasti, Ghasem Ghalamfarsa, Hamed Mohammadi, Mozhdeh Sojoodi, Farhad Jadidi-Niaragh
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
This study evaluated the distribution of the crizotinib patient information brochure (PIB) in Europe and patient knowledge of the key messages in the PIB. A cross‐sectional survey was conducted in 10 European countries among pa tients who received crizotinib to ascertain whether each patient received and read the PIB, and his/her knowledge of its key messages on hepatotoxicity, interstitial lung disease/pneumonitis, QTc prolongation, bradycardia, and vision disorders. Of the 341 patients contacted, 40 responded (11.7%), an d 39 patients were eligible. A total of 77% of respondents acknowledged receiving the PIB, of which...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractOur objective was to examine the trends and variation in opioid prescribing in Estonia from 2011 to 2017. This retrospective cross ‐sectional study is based on a nationwide prescription medicines database. We stratified the analysis by treatment indication (cancer vs noncancer pain). Between 2011 and 2017, annual opioid prescribing rates increased by 67% (from 82.9 to 138.6 prescriptions per 1000 population). The annual numbe r of prescriptions per patient did not change substantially (from 2.94 in 2011 to 2.87 in 2017), and was higher among cancer patients (5.07 vs 2.67 annual prescriptions per cancer and noncan...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
A new blood test that analyses methylation of circulating cell-free DNA can detect more than 50 types of cancer, as well as where the cancer originated.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
More News: Biology | Cancer | Cancer & Oncology | Cancer Therapy | Cancer Vaccines | Chemotherapy | Genetics | Immunotherapy | Radiation Therapy | Study | Vaccines