Reduced Esophageal Contractility Is Associated with Dysplasia Progression in Barrett ’s Esophagus: A Multicenter Cohort Study

ConclusionIn this retrospective study of 193 BE patients, the majority exhibited abnormal esophageal motor function. Reduced esophageal contractility was independently associated with dysplastic progression in BE. Characterizing esophageal physiology in BE may help to risk stratify patients.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research

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CONCLUSION: Our training simulator would be helpful in training medical students because it provides an immersive environment. PMID: 32233159 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Conditions:   Pancreas Cancer;   Cancer of the Pancreas;   Pancreas Adenocarcinoma Interventions:   Device: MR-guided stereotactic body radiation therapy;   Drug: Defactinib;   Procedure: Tumor biopsy;   Procedure: Research blood draw Sponsor:   Washington University School of Medicine Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Prostate Adenocarcinoma;   Obesity, Morbid Interventions:   Device: Bead Block 300-500 um;   Behavioral: Weight Management;   Drug: Lupron Sponsors:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;   Maryland Cigarette Restitution Fund Not yet recruiting
Source: - Category: Research Source Type: clinical trials
In this study, we discovered that higher ELFN1-AS1 expression indicated shorter patient survival in pan-cancer, including ESCA, using online The Cancer Genome Atlas (TCGA) tools. The lncRNA ELFN1-AS1 was significantly up-regulated in ESCA tissues and cell lines when compared with the counterparts. Down-regulation of ELFN1-AS1 restrained cell proliferation, migration and invasion of ESCA in vitro. In addition, we found that the expression of microRNA-183-3p (miR-183-3p) and ELFN1-AS1 or glutamine-fructose-6-phosphate transaminase 1 (GFPT1) were inversely correlated in ESCA. Both ELFN1-AS1 and GFPT1 are direct targets of miR...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
In this study, we examined the effect of laparoscopic-guided transversus abdominis plane block (LG TAP) for further optimizing multimodal pain control.MethodsThis is a retrospective analysis of a prospectively collected database of 140 consecutive patients undergoing LSG without TAP block (pre-TAP group) compared to 131 patients undergoing LSG with LGTAP (TAP group). All operations were performed laparoscopically utilizing uniform clinical pathways. Baseline characteristics for both groups were comparable. Both groups received standardized anesthesia. Outcomes included time to postoperative ambulation, pain scores, PCA vol...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
AbstractBackgroundA procedure-based laparoscopic liver resection (LLR) classification (IMM classification) stratified 11 different LLR procedures into 3 grades. IMM classification assessed the difficulty of LLR differently than an index-based LLR classification (IWATE criteria), which scored each procedure on an index scale of 12. We validated the difference of 3 IMM grades using an external cohort, evaluated the IMM classification using the scores of the IWATE criteria, and compared the performance of IMM classification with the IWATE criteria and the minor/major classification.MethodsPatients undergoing LLR without simul...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionsThis is the first report of cognitive improvements following VSG and the first direct comparison of cognitive improvements following RYGB and VSG. Short-term improvements in specific domains of cognitive function are observed at the beginning of the active weight loss phase following bariatric surgery that persisted to 3  months. The anatomical distinction between the two surgeries and resulting differential metabolic profiles may be responsible for the improvements in attention observed following RYGB but not following VSG.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionsWeight loss after EGJR is sustained up to 5  years after revision with little effect on medical comorbidities. Patients with a greater reduction in stoma diameter experienced superior weight loss.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
In this study, wound-related outcomes are examined, comparing patients who underwent surgery before (Group 1) versus after (Group 2) this intervention. Statistical analysis performed utilizingt tests and Chi square analysis;p 
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Laparoscopic sleeve gastrectomy (SG) has become the dominant bariatric operation despite a lack of long-term data on weight maintenance, resolution of co-morbidities, and side effects. Morbidly obese patients have increased prevalence of esophagitis [1], symptomatic gastroesophageal reflux disease (GERD) [1], and esophageal dysmotility [2] compared with the general population. They are also at increased risk of developing complications of long-term acid reflux including Barrett ’s esophagus [3] and lower esophageal and junctional adenocarcinoma [3,4].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Paired editorial Source Type: research
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