Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes

Conclusions: Our findings indicate that DATS protects against hyperglycemia-induced ROS-mediated apoptosis by upregulating the PI3K/Akt/Nrf2 pathway, which further activates Nrf2-regulated antioxidant enzymes in cardiomyocytes exposed to HG.

Source: International Journal of Cardiology - March 1, 2013 Category: Cardiology Authors: Cheng-Yen Tsai, Chien-Chung Wang, Tung-Yuan Lai, Han-Nien Tsu, Chung-Hsing Wang, Hsin-Yueh Liang, Wei-Wen Kuo Tags: Original Articles Source Type: research