Numerous ballooned neurons in a 94-year-old man with dementia with Lewy bodies

Cortical swollen neurons with achromasia, described as ballooned neurons (BNs), are hallmark of neurodegenerative diseases such as Pick body disease, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and argyrophilic grain disease (AGD) [1]. BNs are also found less frequently in Alzheimer's disease (AD) and Parkinson's disease (PD), while their role in pathological differentiation remains to be clarified [2]. We experienced an autopsy case with abundant BNs in a 94-year-old man with clinico-pathologically confirmed dementia with Lewy bodies (DLB).

Source: Journal of the Neurological Sciences - February 3, 2020 Category: Neurology Authors: Takahiro Takeda, Toshiki Uchihara, Takashi Endo, Masanobu Kitagawa, Katsuiku Hirokawa, Takayoshi Kobayashi, Shuta Toru Tags: Letter to the Editor Source Type: research