Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response after Myocardial Infarction.

Conclusions: Our findings suggest that transiently altering sphingolipid metabolism through AC overexpression is sufficient and necessary to induce cardioprotection post MI, thereby highlighting the therapeutic potential of AC modRNA in ischemic heart disease. PMID: 31992066 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31992066?dopt=Abstract

Source: Circulation - January 28, 2020 Category: Cardiology Authors: Hadas Y, Vincek AS, Youssef E, Żak MM, Chepurko E, Sultana N, Sharkar MTK, Guo N, Komargodski R, Kurian AA, Kaur K, Magadum A, Fargnoli A, Katz MG, Hossain N, Kenigsberg E, Dubois NC, Schadt E, Hajjar R, Eliyahu E, Zangi L Tags: Circulation Source Type: research