Protocol for the Optimune trial: a randomized controlled trial evaluating a novel Internet intervention for breast cancer survivors

DiscussionResults of this RCT are expected to extend the body of knowledge with regard to the effectiveness of CBT-based Internet interventions for female breast cancer survivors.Trial registrationClinicalTrials.gov,NCT03643640. Registered on 23 August 2018.
Source: Trials - Category: Research Source Type: clinical trials

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ConclusionsThe presence of a composite profile of psychological and menopause symptoms prior to AET initiation may help to identify early treatment non-adherence. Results can be used to identify patients at risk for non-adherence and to guide psychological and symptom management interventions.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
This study examined cross-sectional and prospective relationships between subjective (experiential avoidance, expressive suppression, and cognitive reappraisal) and objective (high-frequency heart rate variability) measures of ER and clusters of psychological symptoms among women receiving radiation therapy for breast cancer. Method A total of 81 women completed a battery of self-report scales before (T1) and after (T2) radiotherapy, including measures of anxiety, depression, fear of cancer recurrence, insomnia, fatigue, pain, and cognitive impairments. Resting high-frequency heart rate variability was measured at T1. ...
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
This article describes cognitive behavioral therapy (CBT) for women with problematic menopausal symptoms, and provides the evidence from clinical trials of women going through the menopause, women with breast cancer treatment-induced symptoms and women with problematic symptoms in a work context. The CBT focus is primarily on vasomotor symptoms (VMS) but it also targets stress, low mood and sleep problems. CBT is a brief therapy (four to six sessions) that is theory- and evidence-based; it is acceptable to women and effectively reduces the impact of VMS, improves sleep and has benefits to quality of life. VMS frequency is ...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
Conditions:   Fatigue;   Depression, Anxiety;   Insomnia;   Hot Flashes;   Quality of Life Intervention:   Other: Acupuncture; based on Tradidtional Chinese Medicine Sponsors:   Kristiania University College;   Norwegian Cancer Society;   University of Bergen;   Memorial Sloan Kettering Cancer Center;   Dana-Farber Cancer Institute;   University Hospital, Akershus;   University of York;   University of Tromso Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
DiscussionThis is the first randomised controlled trial to combine CBT and BLT for the treatment of sleep disturbance in women with breast cancer. This novel design addresses the multiple causal factors for sleep complaints in this population. Results from this trial will advance knowledge in this field and may have important clinical implications for how best to treat sleep disturbance and insomnia in this population. If effective, the largely email-based format of the intervention would allow for relatively easy translation.Trial RegistrationAustralian New Zealand Clinical Trials Registry (ANZCTR),ACTRN12618001255279. Re...
Source: Trials - Category: Research Source Type: clinical trials
Conclusions Our findings can contribute to the development of breast cancer survivorship care plans by emphasizing posttreatment SM. Implications for Practice Future SM support intervention for BCSs after treatment should focus on training SM skills, enhancing the survivor-provider relationship, and building survivor self-confidence.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
CONCLUSION: In a context of impairments in mental functioning, sexual enjoyment, symptoms burden, and poor future self-health perspective, breast cancer produced a mean HSU of 0.712. After a period of routine care, there was a small improvement in quality of life, however lower utility estimates were particularly observed in patients with advanced disease and undergoing multiple chemotherapy regimens. PMID: 31106611 [PubMed - as supplied by publisher]
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Karin Meissner1,2*, Nicola Talsky1, Elisabeth Olliges1,2, Carmen Jacob1,3,4, Oliver J. Stötzer5, Christoph Salat5, Michael Braun6 and Raluca Flondor1 1Institute of Medical Psychology, Faculty of Medicine, LMU Munich, Munich, Germany 2Division of Health Promotion, Coburg University of Applied Sciences, Coburg, Germany 3Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom 4Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom 5Haematology and Oncology, Outpatient Cancer Ca...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Abstract Cancer-related fatigue (CRF) is subjective and has wide inter-individual variability. Given that leptin is commonly associated with fatigue syndrome, its use as a potential biomarker for CRF is being investigated. The primary objective of this study was to evaluate the association between leptin and CRF in early-stage breast cancer patients receiving chemotherapy. In a prospective cohort study, patients completed assessments at baseline (T1), during chemotherapy (T2) and after chemotherapy (T3). Levels of plasma leptin and adipokines were measured using a Luminex bead-immunoassay and CRF was measured usin...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
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