Correlation of microglial activation with white matter changes in dementia with Lewy bodies

Publication date: Available online 28 January 2020Source: NeuroImage: ClinicalAuthor(s): Nicolas Nicastro, Elijah Mak, Guy B. Williams, Ajenthan Surendranathan, William Richard Bevan-Jones, Luca Passamonti, Patricia Vazquez Rodriguez, Li Su, Robert Arnold, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, James B. Rowe, John T. O'brienAbstractDementia with Lewy bodies (DLB) is characterized by alpha-synuclein protein deposition with variable degree of concurrent Alzheimer's pathology. Neuroinflammation is also increasingly recognized as a significant contributor to degeneration. We aimed to examine the relationship between microglial activation as measured with [11C]-PK11195 brain PET, MR diffusion tensor imaging (DTI) and grey matter atrophy in DLB. Nineteen clinically probable DLB and 20 similarly aged controls underwent 3T structural MRI (T1-weighted) and diffusion-weighted imaging. Eighteen DLB subjects also underwent [11C]-PK11195 PET imaging and 15 had [11C]-Pittsburgh compound B amyloid PET, resulting in 9/15 being amyloid-positive. We used Computational Anatomy Toolbox (CAT12) for volume-based morphometry (VBM) and Tract-Based Spatial Statistics (TBSS) for DTI to assess group comparisons between DLB and controls and to identify associations of [11C]-PK11195 binding with grey/white matter changes and cognitive score in DLB patients. VBM analyses showed that DLB had extensive reduction of grey matter volume in superior frontal, temporal, parietal and occipital cortice...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research