Depression heterogeneity and its biological underpinnings: towards immuno-metabolic depression

Epidemiological evidence indicates dysregulated homeostatic biological pathways in depressed patients, such as increased inflammation and disrupted energy-regulating neuroendocrine signaling (e.g. leptin, insulin). Alterations in these biological pathways may explain the considerable comorbidity between depression and cardiometabolic conditions (e.g. obesity, metabolic syndrome, diabetes) and represent a promising target for intervention. This review will describe how immuno-metabolic dysregulations vary as a function of depression heterogeneity by illustrating that such biological dysregulations: 1) map more consistently to “atypical” behavioral symptoms reflecting altered energy intake/expenditure balance (hyperphagia, weight gain, hypersomnia, fatigue and leaden paralysis); and 2) may moderate the antidepressant effects of standard or novel (e.g.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research

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Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Karolina Nowak, Marcin Zawadzki, Tomasz JurekAbstractPostmortem diagnosis of hyperglycaemia is a challenge in forensic medicine. Glycated haemoglobin (HbA1c) is considered one of the markers providing an alternative to postmortem determinations of glucose concentration. On the other hand, glycated albumin (GA) may be determined in cases of difficulty in determining HbA1c.The aim of this study was to implement and evaluate the usefulness of methods enabling determination of HbA1c an GA in postmortem material (HbA1c–peripheral blood, GA&ndas...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 20 February 2020Source: Catalysis TodayAuthor(s): Thi Phuong Thao Nguyen, Ki Hyuck Yang, Moon Hyeon Kim, Yong Seok HongAbstractFe2O3-promoted V2O5-WO3/TiO2 catalysts with high Fe2O3-to-V2O5 ratios (3.4 – 6) have been prepared for the selective reduction of NO with NH3 (NH3-SCR) and extensively characterized using various spectroscopic measurements. No crystalline iron oxides were indicated even for 8% Fe2O3-promoted V2O5-WO3/TiO2 but distorted α-Fe2O3 crystallites were observed in a XRD pattern for 7.04% Fe2O3-promoted WO3/TiO2. Both Raman and XPS measurements suggest the form...
Source: Catalysis Today - Category: Chemistry Source Type: research
Publication date: Available online 20 February 2020Source: MethodsXAuthor(s): Luis O. Soto-Rojas, Cecilia Bañuelos, Linda Garces-Ramirez, Claudia Luna-Herrera, Yazmin M. Flores-Martínez, Guadalupe Soto-Rodríguez, Bismark Gatica-García, Francisco E. López-Salas, José Ayala-Dávila, María E. Gutiérrez-Castillo, América Padilla-Viveros, Fidel de la Cruz-López, Irma A. Martínez-Davila, Daniel Martinez-FongAbstractAn animal model, suitable for resembling Parkinson's disease (PD) progress, should show both, motor and non-motor alterations. However...
Source: MethodsX - Category: Science Source Type: research
ABSTRACT: Introduction: In high-income countries, persons of high socioeconomic status (SES) have a lower cardiovascular risk. However, in middle and low-income countries, the results are controversial. Objective: To evaluate the association between family income and cardiovascular risk factors in young adults. Methods: A total of 2,063 individuals of a birth cohort initiated in 1978/79 in the city of Ribeir ão Preto, Brazil, were evaluated at age of 23/25 years. Cardiovascular risk factors (hypertension, sedentary lifestyle, smoking, low high-density lipoprotein (HDL)-cholesterol, high low-density lipoprotein (LDL)...
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Conclusion: The findings, such as the inverse relationship with tuberculosis treatment discontinuation in the group of people with comorbidity, reinforce the importance of integrated actions in health services to change the scenario of this challenging comorbidity.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Conclusion: Age group, sex, household per capita income, and body mass index status were associated with SSB intake.RESUMO: Introdu ção: A ingestão de bebidas açucaradas varia de acordo com as características da população. Objetivos: Investigar o consumo de bebidas açucaradas e os fatores demográficos, socioeconômicos e de estilo de vida associados ao seu consumo em adolescentes, adultos e idosos residentes em São Paulo. Métodos: Foram utilizados dados do Inquérito de Saúde de São Paulo, estudo transversal de base popula...
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
ConclusionThe results of the meta-analysis were found to be associated with PCOS condition. These genetic predisposition and pre prediction can interpret the chance of getting PCOS condition.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
CONCLUSIONS: Endogenous GIP and GLP-1 lower postprandial plasma glucose excursions and stimulate insulin secretion but only endogenous GIP affects gallbladder motility. The two incretin hormones potentiate each other's effects in the control of postprandial glycemia in healthy men. PMID: 32077470 [PubMed - in process]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Abstract BACKGROUND: The question of whether there is daytime time variation in diet-induced thermogenesis (DIT) has not been clearly answered. Moreover, it is unclear whether a potential diurnal variation in DIT is preserved during hypocaloric nutrition. OBJECTIVE: We hypothesized that DIT varies depending on the time of day and explored whether this physiological regulation is preserved after low-calorie compared with high-calorie intake. DESIGN: Under blinded conditions, 16 normal-weight men twice underwent a 3-day in-laboratory, randomized, crossover study. Volunteers consumed a predetermined low-cal...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
PsyCoLaus: une étude prospective des liens entre la santé mentale et les maladies cardiovasculaires. Praxis (Bern 1994). 2020 Jan;109(1):9-12 Authors: Preisig M, Strippoli MF, Vandeleur CL Abstract PsyCoLaus: A Prospective Study of the Links between Mental Health and Cardiovascular Diseases Abstract. PsyCoLaus, which includes an investigation of mental disorders and cognitive functioning, aims to determine the prevalence and the course of mental disorders in the general population and to study the mechanisms underlying the association between these disorders and cardiovascular diseases. ...
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
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