Investigation of gut microbiome changes in type 1 diabetic mellitus rats based on high-throughput sequencing

This study suggests that intestinal inflammation and reduction of short chain fatty acids (SCFAs) caused by the imbalance of gut microbiota are crucial to the pathogenesis of T1DM.Graphical abstractIn this study, LEfSe multilevel species hierarchical tree directly reflects the differences of gut microbiota between control and T1DM rats at the Phylum-to-Family level, the result showed that the gut microbiome of T1DM rats changed significantly. The abundance of pathogenic bacteria associated with infection and inflammation in T1DM rats was up-regulated such as Ruminococcaceae, Shigella, Enterococcus, Streptococcus, Rothia and Alistipes, while the abundance of beneficial bacteria and bacteria producing SCFAs were reduced such as Lactobacillus, Faecalitalea, Butyricicoccus and Allobaculum.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research