Migrations do not modify Mycobacterium tuberculosis resistance rates: a 20-year retrospective study

AbstractTuberculosis (TB) caused by resistant strains is becoming a public health concern also in high-income countries. In Pavia province, Northern Italy, the prevalence of foreign-born has increased in recent years. Nevertheless, it is unclear if this has modified epidemiology and resistance patterns ofMycobacterium tuberculosis. We retrospectively collected data on all theMycobacterium tuberculosis strains isolated by culture in the microbiology reference laboratory of the province of Pavia from 01/01/1998 to 31/12/2017. Overall, 919 patients were identified, 320 were foreign-born (34.8%). The proportion of cases due to foreign-born patients increased during the study period as did resistance to isoniazid (INH) (p = 0.01), while resistance to rifampicin (RIF) did not (p = 0.8). INH and RIF resistance were comparable among Italian and foreign-born patients (7.9% vs 9.7% for INH and 4% vs 5% for RIF, respectively). Twenty-height (3.05%) patients harboured MDR strains. Prevalence of MDR strains was not different between Italians and foreign-born patients (2.8% vs 3.4%,p = 0.6). During the study period the proportion of TB cases due to foreign-born patients and INH resistance increased. This increase was equal among Italian and foreign-born patients. Migrants in our area are not a driver of resistance to anti-mycobacterial drugs.
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research

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Sunil Kumar RainaJournal of Global Infectious Diseases 2020 12(1):3-4
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: Epidemiology, occupational and environmental lung disease, Respiratory infections and tuberculosis Reviews Source Type: research
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Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: Epidemiology, occupational and environmental lung disease, Respiratory infections and tuberculosis Editorial Source Type: research
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Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Clinical Radiology - Category: Radiology Authors: Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Medical Imagery Source Type: research
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Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Images in Radiology Source Type: research
Conditions:   Tuberculosis;   Tuberculosis Infection Interventions:   Other: Multiple blood samples;   Other: Single blood sample Sponsor:   Hospices Civils de Lyon Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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