Marine resources effective in controlling and treating diabetes and its associated complications

In this study, we investigated different bioactive compounds in marine resources that may be potentially useful in treating or managing diabetes, as well as describe the various therapeutic mechanisms affecting diabetes and its complications, including inhibition of α-amylase, α-glucosidase, β -glucosidase, glycogen synthase kinase 3β (GSK-3β), lipase, aldose reductase, protein tyrosine phosphatases 1B (PTP1B) and dipeptidyl peptidase IV   (DPP-4), prevention of insulin resistance, increased phosphorylation of the AMP-activated protein kinase (AMPK) and adjusting the metabolism of glucose and lipids, stimulation of natural killer cells, anti-inflammatory effects, induction of liver antioxidant activity, reduction in oxidative stress and protection of β-pancreatic cells. This review focuses on the presentation of previous studies performed on a variety of potential marine resources against diabetes.
Source: Process Biochemistry - Category: Biochemistry Source Type: research

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Authors: Abdel Aziz SM, Ahmed OM, Abd El-Twab SM, Al-Muzafar HM, Amin KA, Abdel-Gabbar M Abstract The present study aimed to evaluate the antihyperglycemic effects of Musa paradisiaca (M. paradisiaca) leaf and fruit peel hydroethanolic extracts and to suggest their probable mode of actions in nicotinamide (NA)/streptozotocin (STZ)-induced diabetic rats. The leaf and fruit peel hydroethanolic extracts were analyzed by GC-MS that indicated the presence of phytol, octadecatrienoic acid, hexadecanoic acid, and octadecadienoic acid as major components in the leaf extract and vitamin E, octadecenamide, β-sitosterol,...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
This study focuses on understanding the effects of moxibustion with a seed-sized moxa cone on HLP and the potential metabolic pathways associated with HLP. An automatic analyzer was used to measure the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in healthy controls (HCs), HLP patients, and in patients before moxibustion with seed-sized moxa cone treatment (BMT) and after moxibustion treatment (AMT). Liquid chromatography-mass spectrometry and pathway analyses were performed using differential plasma metabolites derived fr...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusion: We established credible evidence that Morus mesozygia leaf extract has hypoglycemic effects between 400 mg/kg and 800 mg/kg and that it is safe on the liver and kidneys of wistar rats at doses less than 800 mg/kg. PMID: 32030095 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
ConclusionsThe study presents an exhaustive and updated review on the traditional, pharmacological and phytochemical aspects of H. indicus with notes on its quality control and toxicological information. Although the crude extracts of H. indicus exhibit an array of pharmacological activities, it is high time to identify more active phyto-constituents by bioactivity-guided isolation besides elucidating their structure-activity relationship. More designed investigations are needed to comprehend the multi-target network pharmacology, to clarify the molecular mode of action and to ascertain the efficacious doses of H. indicus....
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Oguntibeju OO Abstract The use of medicinal plants in the treatment and management of diabetes mellitus is not very popular in Europe and USA as it is in Africa due to adequate availability of synthetic drugs and insulin for the effective management of diabetes in the western countries. In Africa, over 80% of the population live in poor resource settings and depend on medicinal plants for the treatment of various diseases including diabetes mellitus. Africa is very rich in medicinal plants and many of these plants are used in the treatment of diabetes mellitus. These plants play important role as alternati...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research
As a compound Chinese medicine, Zhenqing Recipe (ZQR) has been shown to ameliorate hyperglycemia, hyperlipidemia, fatty liver and insulin resistance in patients with diabetes and diabetic rats. In this paper, ...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
ConclusionP. karwinskii leaf extract inhibited reactive oxygen species and exerted an anti-inflammatory effect. Moreover, this extract did not induce gastric damage in the animals. The bioactivity of the species was found to support its traditional use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing the side effects associated with Nonsteroidal anti-inflammatory drugs. It can also be employed to treat other pathological conditions associated with oxidative stress. The findings herein form the basis for the future discovery of natural products that may serve as safe alternat...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Qu KS, Li Y, Liang Y, Hu XJ, Wang XY, Chen X, Que HF Abstract Background: Diabetic foot ulcer (DFU) is one of the most common complications of diabetes mellitus, with the wound not healing as expected and healing slowly. Poor control can develop into gangrene and even amputation. Currently, the existing treatments are not satisfactory enough. In China, KangFuXin liquid (KFXL) has been clinically used to treat DFU and has shown good clinical efficacy. In order to provide more reference to clinicians and experts, evidence of efficacy for it needs to be further rigorously evaluated. Methods: Eight electro...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
I came across an article inForbes discussing beauty and wellness trends for 2020 (see:9 Beauty And Wellness Trend Predictions For 2020 And Beyond). Included in the article was the graphic shown below that categorizes the global wellness economy for 2017 into various segments. All of this raised the question in my mind about how health systems can pursue a portion of this huge wellness market without straying too far from their roots. First, take a look at the graph below.I believe that it would be relatively easy for health systems to become more engaged in three segments of the global wellness industry as shown above...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Health Wearable Healthcare Delivery Healthcare Innovations Medical Consumerism Population Health Public Health Quality of Care Source Type: blogs
The objective of this work was to determine the toxic effect of the aqueous extract of Calea ternifolia (C. zacatechichi), known popularly as "dream herb" in vivo and in vitro in order to validate its safety. In vivo, the extract had moderate toxicity on A. salina. In vitro, the extract induced eryptosis of 73% at a concentration of 100 μg·mL-1 and it inhibited CYP3A by 99% at a concentration of 375 μg/mL. After administering 8.5 mg/kg of C. ternifolia to rats, we found a reduction in platelets and leukocytes and an increase in urea and the liver enzymes alanine aminotransferase ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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