Marine resources effective in controlling and treating diabetes and its associated complications

In this study, we investigated different bioactive compounds in marine resources that may be potentially useful in treating or managing diabetes, as well as describe the various therapeutic mechanisms affecting diabetes and its complications, including inhibition of α-amylase, α-glucosidase, β -glucosidase, glycogen synthase kinase 3β (GSK-3β), lipase, aldose reductase, protein tyrosine phosphatases 1B (PTP1B) and dipeptidyl peptidase IV   (DPP-4), prevention of insulin resistance, increased phosphorylation of the AMP-activated protein kinase (AMPK) and adjusting the metabolism of glucose and lipids, stimulation of natural killer cells, anti-inflammatory effects, induction of liver antioxidant activity, reduction in oxidative stress and protection of β-pancreatic cells. This review focuses on the presentation of previous studies performed on a variety of potential marine resources against diabetes.
Source: Process Biochemistry - Category: Biochemistry Source Type: research