PD-L1 gene promoter methylation represents a potential diagnostic marker in advanced gastric cancer.

In conclusion, high methylation levels of the PD-L1 promoter region may be a faciliatory mechanism enabling gastric cancer tumorigenesis, and may also represent an independent prognostic factor for chemotherapeutic efficacy in patients with advanced gastric cancer. PMID: 31966052 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31966052?dopt=Abstract

Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research