Glucose restriction combined with chemotherapy decreases telomere length and cancer antigen-125 secretion in ovarian carcinoma.

In conclusion, the combination of chemotherapy and glucose restriction was observed to decrease Ca-125 secretion and telomerase expression leading to shortening in telomere length. Thus, decreasing glucose availability for OC cells during treatment may lead to a better clinical outcome and potentially improve the prognosis of patients with OC. PMID: 31966066 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31966066?dopt=Abstract

Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research