Study Finds No Association Between Herpes Virus and Alzheimer's

While the findings contradict previous studies that have linked human herpesvirus 6 to the neurodegenerative disease, they do not eliminate the possibility of a relationship.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news

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DISCUSSION: These results, in accordance with a solid pathophysiological rationale, suggest a role for HSV-1 in AD development among subjects with a genetic susceptibility factor, the APOE4 allele. PMID: 31914220 [PubMed - in process]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts. BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
There is a reasonable mechanism by which persistent viral infections might raise the risk of Alzheimer's disease: amyloid-β is an antimicrobial peptide, a part of the innate immune system. The presence of viral particles will contribute to greater production of amyloid-β, which will accelerate the pace at which amyloid-β might aggregate in older individuals due to an imbalance between production and clearance. The aggregates then cause the usual progression to neural inflammation, damage, and cognitive decline. Does the epidemiological data support a role for persistent herpes viruses in Alzheimer's risk, ho...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(Baylor College of Medicine) Researchers refute the link between increased levels of herpes virus and Alzheimer's disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusion: This review of the literature strongly suggests that mercury can be a cause of Alzheimer’s Disease.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Hypothesis Source Type: research
This commentary challenges the premise of a viral etiology in Alzheimer's disease by discussing evidence that Herpes simplex virus reactivation reduces progression to Alzheimer's disease, and also proposing that viral reactivation is a compensatory reaction to other causal exposures in Alzheimer's disease pathophysiology. AbstractMany have described the molecular mechanisms underpinning the viral etiology of Alzheimer's disease. This commentary challenges this premise by discussing evidence that Herpes simplex virus reactivation reduces progression to Alzheimer's disease, and also proposing that viral reactivation is a com...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: Commentary Source Type: research
Viruses, Vol. 11, Pages 966: Persistent Infection with Herpes Simplex Virus 1 and Alzheimer’s Disease—A Call to Study How Variability in Both Virus and Host may Impact Disease Viruses doi: 10.3390/v11100966 Authors: Colleen A. Mangold Moriah L. Szpara Increasing attention has focused on the contributions of persistent microbial infections with the manifestation of disease later in life, including neurodegenerative conditions such as Alzheimer’s disease (AD). Current data has shown the presence of herpes simplex virus 1 (HSV-1) in regions of the brain that are impacted by AD in elderly indivi...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Publication date: Available online 15 October 2019Source: Brain, Behavior, and ImmunityAuthor(s): Jason J. Woods, Kathryn A. Skelding, Kristy L. Martin, Ritambhara Aryal, Estelle Sontag, Daniel M. Johnstone, Jay C. Horvat, Philip M. Hansbro, Elizabeth A. MilwardAbstractAlzheimer’s disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Abstract Alzheimer's disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has focused on infectious pathogens that may colonize the brain such as herpes simplex type I. Some researchers have proposed the respiratory bacteria Chlamydia pneumoniae may also be implicated in Alzheimer's disease, however this remains controversial. This r...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Abstract Microglia, as brain-resident macrophages, are the first line of defense against brain invading pathogens. Further, their dysfunction has been recognized to be closely associated with mounting CNS diseases. Of note, chronic HSV-1 infection leads to the persistent activation of microglia, which elicit a comprehensive response by generating certain factors with neurotoxic and neuroprotective effects. CNS infection with HSV-1 results in herpes simplex encephalitis and herpes simplex keratitis. Microglial immune response plays a crucial role in the development of these diseases. Moreover, HSV-1 infection is st...
Source: Critical Reviews in Microbiology - Category: Microbiology Authors: Tags: Crit Rev Microbiol Source Type: research
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