Immune system cells contribute to the invading capacity of brain tumours

(Universitat Autonoma de Barcelona) An article published in Brain Communications, coordinated by Carlos Barcia, researcher at Institut de Neuroci è ncies de la UAB, describes how the immune system facilitates the expansion of tumour cells in the brain. The study was performed on human samples of glioblastoma, the most aggressive brain tumour, and on cell culture models. These findings will help to develop treatments for this type of tumour, for which there is not an effective therapy at the moment.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Conclusions Symptom management in conjunction with PBT comprises a process of action, thoughts, and emotions. The concepts that emerged indicated patients' symptom management strategies were based on their own resources. Implications for Practice It is important that PBT facilities develop an approach that facilitates the symptom management process based on patients' experiences of symptoms, as well as their actions and available resources.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES: ONLINE ONLY Source Type: research
(University of Missouri-Columbia) A retrospective study from the University of Missouri School of Medicine and MU Health Care showed patients who underwent surveillance imaging after surgery for brain tumor resection did not have better outcomes than patients who did not have imaging and returned when they felt symptoms of recurrence.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(InSilico Medicine) New AI-powered discovery generative biology and generative chemistry effort targeting brain tumors with the focus on GBM launches at Insilico Medicine.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Conclusions: Percentage of signal recovery shows low recovery values in metastases, intermediate recovery values in glioma, and overshoot in lymphoma. PSR values show lower overlap than rCBV between lymphoma and metastases; and between high grade glioma and metastases. PSR difference is also higher than rCBV between low- and high-grade gliomas. Hence, PSR can potentially help as an additional perfusion parameter in the preoperative differentiation of these tumors.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
llis Di C.o Medulloblastoma (MB) is the most common malignant brain tumor in children, and it is classified into four biological subgroups: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. The current treatment is surgery, followed by irradiation and chemotherapy. Unfortunately, these therapies are only partially effective. Citron kinase protein (CITK) has been proposed as a promising target for SHH MB, whose inactivation leads to DNA damage and apoptosis. D283 and D341 cell lines (Group 3/Group 4 MB) were silenced with established siRNA sequences against CITK, to assess the direct effects of its loss. Next, D283, D...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In this study, we found that eriodictyol has anti-tumor activity in lung, colon, breast, pancreas, and liver cancer, and most significantly in glioma cell lines. Eriodictyol dose- and time-dependently suppresses cell proliferation, migration, and invasion in U87MG and CHG-5 glioma cells. In addition, eriodictyol induces apoptosis in U87MG and CHG-5 cells, as evaluated by flow cytometry, immunofluorescence, and Western blot. Furthermore, eriodictyol downregulates the phosphoinositide 3-kinase (PI3K)/Akt/NF-κB signaling pathway in a concentration-dependent manner. Moreover, the effects of eriodictyol on the apoptosis o...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CCR Grand Rounds Duane A. Mitchell, M.D., Ph.D. is Co-Director of the Preston A. Wells Jr. Center for Brain Tumor Therapy and Director of the UF Brain Tumor Immunotherapy Program. He is the Phyllis Kottler Friedman Professor in the Department of Neurosurgery and the State of Florida Endowed Cancer Research Chair at the University of Florida College of Medicine. Dr. Mitchell graduated from Rutgers College in New Brunswick, New Jersey with a bachelor ’ s degree in biology before receiving his medical degree and doctorate degree in immunology from Duke University in Durham, North Carolina in 2001. He completed post-grad...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
A new simple blood test for brain tumours that could be used by GPs in primary care will be developed thanks to funding of nearly £ 500,000 by Cancer Research UK. Around 60,000 patients in the UK are living with a brain tumour but only 20 per cent of patients are still alive five years after diagnosis, partly because they present late with large inoperable tumours.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Grants and Awards, Health, International, Research; Faculty of Engineering, Faculty of Engineering, School of Computer Science, Electrical and Electronic Engineering, and Engineering Maths, Faculty of Health Sciences, Faculty of Health Sciences, Translati Source Type: news
(University of Bristol) A new simple blood test for brain tumors that could be used by GPs in primary care is being developed thanks to funding of nearly £ 500,000 by Cancer Research UK. Around 60,000 patients in the UK are living with a brain tumor but only 20% of patients are still alive five years after diagnosis, partly because they present late with large inoperable tumors.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractPediatric brain tumors are the leading cause of childhood cancer mortality with medulloblastoma (MB) representing the most frequent malignant tumor. Although standardization of therapy resulted in a 2-fold reduction in mortality in patients with MB by 2002, it became clear that further improvements in clinical outcome would require a deeper understanding of the biology of MB. Employing the four main molecular MB subgroups (Wnt, Shh, Group 3 and Group 4), a restratification into clinicogenomic risk categories quantified an unacceptable survival for the high-risk group, urging researchers to focus their efforts towar...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
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