Effects of Moist Exposed Burn Therapy and Ointment (MEBT/MEBO) on the autophagy mTOR signalling pathway in diabetic ulcer wounds.

Effects of Moist Exposed Burn Therapy and Ointment (MEBT/MEBO) on the autophagy mTOR signalling pathway in diabetic ulcer wounds. Pharm Biol. 2020 Dec;58(1):124-130 Authors: Zheng A, Ma H, Liu X, Huang Q, Li Z, Wang L, Zeng N, Wu B Abstract Context: Burn therapy (MEBT)/moist exposed burn ointment (MEBO) is an effective traditional Chinese medicine method to treat diabetic wound, but the mechanism is unclear. Autophagy has been proved to be closely related with wound healing, so MEBO/MEBT is hypothesized to promote diabetic wound healing by regulating autophagy.Objective: To explore the mechanism of moist exposed MEBT/MEBO promoting diabetic wound repair.Materials and methods: Eighty male Wistar rats were randomly assigned to control (n = 20) and diabetic group induced by intraperitoneal injection of STZ (n = 60), which were further randomly assigned to MEBO, Kangfuxin and model groups (n = 20 each). All rats underwent full-thickness skin resection in the back. Wound healing was dynamically observed and wound tissues were collected at five time points for pathological examination, autophagosome and the expression of PI3K, Akt and mTOR.Results: The healing time in the control group was the shortest, no statistically significant difference was found between the MEBO and the Kangfuxin group (p = 0.76). The morphology of autophagosomes ranged large to small, which was the most obvious in the MEBO group. T...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

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ConclusionChinese herbal preparation HKSWF has remarkable curative effects on glomerulonephritis animals. HKSWF attenuates pyruvate dehydrogenase to improve glomerular injury.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Highly breathable, oxygen ‐sensing films exhibit bright phosphorescence upon de‐oxygenation, visible with the naked eye. The photograph was taken with a cell phone camera, and the dye was excited with a handheld blue LED flashlight. Integrated spectra show a change in phosphorescence intensity of over 2000% in such films upon deoxygenation. The response is not affected by changes in humidity. AbstractQuantification of tissue oxygen partial pressure (pO2) at the skin surface is crucial for diagnostic applications in burns, reconstructive surgeries, diabetic ulcers, etc. Further, current advances in wearable and communic...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Special Issue Research Article Source Type: research
ORONO, Maine (CBS Local) — New research by the University of Maine shows that wild blueberries may have wound-healing properties. The research shows phenolic acids extracted from wild blueberries significantly promote cell migration and the speed of wound closure. Dorothy Klimis-Zacas, a professor of clinical nutrition at the University of Maine, is working to use these compounds to create a biomedical product prototype like a topical cream that can be applied to wounds, CBS affiliate WABI reported. Dorothy Klimis-Zacas, UMaine professor of clinical nutrition, discovered wild blueberries have properties that promote...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Offbeat Syndicated CBSN Boston Local TV talkers Source Type: news
ConclusionsCACIPLIQ20® can heal chronic wounds of various etiologies, sizes and ages in approximately two months, while being cost-effective. By doing so, this treatment can provide major improvement of quality of life through rapid and complete healing of chronic, hard-to-heal wounds and can reduce the economic burden of chronic wounds for health care agencies.
Source: Wound Medicine - Category: General Medicine Source Type: research
AbstractQuantification of tissue oxygen partial pressure (pO2) at the skin surface is crucial for diagnostic applications in burns, reconstructive surgeries, diabetic ulcers, etc. Further, current advances in wearable and communications technologies have widened the use of trans ‐cutaneous oxygen monitors (TCOM) for home care or even enhance athletic performance. For TCOM technology to find widespread use, devices must function reliably yet independently of changes in environmental conditions, humidity in particular. To this end, we have explored the incorporation of an o xygen‐sensing metalloporphyrin within different...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: SPECIAL ISSUE RESEARCH ARTICLE Source Type: research
AbstractPurpose of ReviewCommercialization of an automated epidermal harvesting device (CelluTome ™, Kinetic Concepts Inc., San Antonio, TX) in the last 6 years has led to numerous publications describing a growing number of clinical applications. The current article reviews this literature while summarizing outcomes.Recent FindingsA total of 20 published reports including 284 automated graft recipients have been published. Complete reepithelialization occurs in 50 –92% of recipient sites, often within 4–18 weeks of graft placement. Donor sites heal without scarring within 1–2 weeks.S...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
Earlier this year, Medgadget reported on the FDA’s clearance of the SEM Scanner, a device created by Los Angeles-based Bruin Biometrics (BBI). The SEM Scanner is a wireless, handheld device that detects changes in sub-epidermal moisture as an i...
Source: Medgadget - Category: Medical Devices Authors: Tags: Critical Care Exclusive Medicine Plastic Surgery Vascular Surgery Source Type: blogs
You're reading 8 Nootropics to Stimulate Your Brain This Fall, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Nootropics is a term coined by Dr. Corneliu E. Giurgea to describe a class of drugs, supplements, and other synthetic and naturally occurring compounds that improve cognitive function in our brains. They’re often called “smart drugs,” as they can help us think faster and more efficiently. Although used by pretty much everyone, these nootropic supplements are especially popular among youn...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement nootropics pickthebrain Source Type: blogs
Authors: Meerovich GA, Akhlyustina EV, Tiganova IG, Lukyanets EA, Makarova EA, Tolordava ER, Yuzhakova OA, Romanishkin ID, Philipova NI, Zhizhimova YS, Romanova YM, Loschenov VB, Gintsburg AL Abstract Antibacterial photodynamic therapy (APDT) is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without them developing resistance in response to treatment.This work was dedicated to the study of photophysical and antibacterial properties of new photosensitizers (PS) bas...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In the minutes after block 4 of the nuclear power plant in Chernobyl exploded, no one knew that they are experiencing a disaster that never happened anywhere before on planet Earth. The public health, environmental, and even the socio-political consequences were disastrous and we can still experience the negative impacts. That’s why we posed the question of what public health authorities, as well as individuals, can do to mitigate the consequences of radiation exposure, and what digital technologies are available for radiation detection. In this respect, after our investigations, it even turned out that it would be b...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Space Medicine astronautics chernobyl disaster fiction Health Healthcare Innovation mars nuclear power plant public health radiation radiation exposure radiation protection technology Source Type: blogs
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