The effector mechanism of siRNA spherical nucleic acids [Biochemistry]

Spherical nucleic acids (SNAs) are nanostructures formed by chemically conjugating short linear strands of oligonucleotides to a nanoparticle template. When made with modified small interfering RNA (siRNA) duplexes, SNAs act as single-entity transfection and gene silencing agents and have been used as lead therapeutic constructs in several disease models. However,...

http://www.pnas.org/content/117/3/1312.short?rss=1

Source: Proceedings of the National Academy of Sciences - January 20, 2020 Category: Science Authors: Gokay Yamankurt, Robert J. Stawicki, Diana M. Posadas, Joseph Q. Nguyen, Richard W. Carthew, Chad A. Mirkin Tags: Physical Sciences Source Type: research