Early ‐stage endometrial cancer, CTNNB1 mutations, and the relation between lymphovascular space invasion and recurrence

ConclusionsThis study supports the importance of lymphovascular space invasion to identify women with significant risk for recurrence in initially low ‐risk, early‐stage endometrial cancer. It also identifiesCTNNB1 as a significant mutation in early ‐stage disease, and although it may not represent a marker for recurrence its high prevalence in early stage disease could have relevance for both pathogenesis and early treatment.

Source: Acta Obstetricia et Gynecologica Scandinavica - January 16, 2020 Category: OBGYN Authors: Sara Imboden, Coya Tapia, Nadja Scheiwiller, Vida Kocbek, Hans J. Altermatt, Jan Janzen, Michael D. Mueller, Brett McKinnon Tags: ORIGINAL RESEARCH ARTICLE Source Type: research