Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients

ConclusionWhile our sample size limits statistical confidence about the differences observed in this study, it was possible to measure and quantify inter-individual and cohort variability in a non-invasive manner. Our study also shows the potential for MRI based measurements of CSF geometry and flow to provide information about   the hydrodynamic environment of the spinal subarachnoid space. These dynamics may be studied further to understand the behavior of CSF solute transport in healthy and diseased states.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research

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This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
People with Amyotrophic Lateral Sclerosis (PwALS) in the advanced phase are critically affected by an almost total loss of mobility and severe communication problems. Scanning access based on the patient ’s int...
Source: Journal of NeuroEngineering and Rehabilitation - Category: Rehabilitation Authors: Tags: Research Source Type: research
ConclusionDTI mapping ofTDP-43G298S mice demonstrated progression in motor areas M1/M2. WBSS and TFAS are useful techniques to localizeTDP-43G298S associated alterations over time in this ALS mouse model, as a biological marker.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
We examined differential tractography on multiple sclerosis, Huntington disease, amyotrophic lateral sclerosis, and epileptic patients. The results showed that the affected pathways shown by differential tractography matched well with the unique clinical symptoms of the patients, and the false discovery rate of the findings could be estimated using a sham setting to provide a reliability measurement. This novel approach enables a quantitative and objective method to monitor neuronal injury in individuals, allowing for diagnostic and prognostic evaluation of brain diseases.Graphical abstract
Source: NeuroImage - Category: Neuroscience Source Type: research
INTRODUCTION: Our pilot study tested the feasibility and performance of an eye-controlled power wheelchair for amyotrophic lateral sclerosis (ALS) patients. METHODS: In this prospective pilot study, participants drove the wheelchair three times aro...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
Publication date: Available online 22 July 2019Source: NeuroImage: ClinicalAuthor(s): Thomas Welton, Jerome J. Maller, R. Marc Lebel, Ek T. Tan, Dominic B. Rowe, Stuart M. GrieveAbstractObjectiveTo construct a clinical diagnostic biomarker using state-of-the-art microstructural MRI in the motor cortex of people with amyotrophic lateral sclerosis (ALS).MethodsClinical and MRI data were obtained from 21 ALS patients (aged 54 ± 14 years, 33% female) and 63 age- and gender-matched controls (aged 48 ± 18 years, 43% female). MRI was acquired at 3T and included T1-weighted scan (for volumetrics), arteria...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusions: Initial in vivo studies in SOD1[asterisk]G93A mice indicated lower binding of [11C]MPC-6827 in transgenic mice compared to wild types. Our initial evaluations suggest that [11C]MPC-6827 can be a potential radiotracer for imaging ALS and other neurodegenerative disorders in which alteration of microtubule is hypothesized.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science II (Neurosciences) Source Type: research
Proton magnetic resonance spectroscopy (MRS) provides a means of measuring cerebral metabolites in vivo relevant to neurodegeneration. In amyotrophic lateral sclerosis (ALS), neurochemical changes reflecting neuronal loss or dysfunction (decreased N-actylaspartate [NAA]) is most significant in the motor cortex and corticospinal tracts. Other neurochemical changes observed include increased myo-inositol (mIns), a putative marker of gliosis. MRS confirmation of involvement of non-motor regions such as the frontal lobes, thalamus, basal ganglia, and cingulum are consistent with the multi-system facet of motor neuron disease w...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Chun Wu1†, Bevan E. Huang1, Guang Chen2, Timothy W. Lovenberg2, David J. Pocalyko1 and Xiang Yao3* 1Computational Sciences, Discovery Sciences, Janssen Research &Development, LLC, Spring House, PA, United States 2Neuroscience Therapeutic Area, Janssen Research &Development, LLC, La Jolla, CA, United States 3Computational Sciences, Discovery Sciences, Janssen Research &Development, LLC, La Jolla, CA, United States Transcriptomics technologies such as next-generation sequencing and microarray platforms provide exciting opportunities for improving diagnosis and treatment of complex diseases. Tra...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion and Perspectives The IL-6/JAK/STAT signaling cascade plays a dominant role in skeletal muscle pathophysiology. IL-6 autocrine, paracrine, and endocrine functions assign to its downstream effectors pivotal importance in skeletal muscle-wasting-associated diseases and other multiple system diseases where muscle acts in communication with other organs. Targeting the components of the JAK/STAT pathway recently emerged as a strategic approach for the treatment of inflammatory diseases and human cancer. This review highlights the opposite outcomes on muscle biology caused by the amount of local and systemic release ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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