Does Cannabis Dependence Add on to the Neurocognitive Impairment Among Patients With Opioid Dependence? A Cross-Sectional Comparative Study.

CONCLUSIONS: Opioid dependence is associated with impairments in decision making, executive function, working memory, and attention. Co-morbid cannabis dependence had similar profiles of cognitive impairments. SCIENTIFIC SIGNIFICANCE: Co-morbid cannabis dependence might not add on to the existing cognitive dysfunction in opioid dependence. Further studies should be done with a larger sample. (Am J Addict 2020;00:00-00). PMID: 31951069 [PubMed - as supplied by publisher]
Source: American Journal on Addictions - Category: Addiction Authors: Tags: Am J Addict Source Type: research

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INTRODUCTION Admission computed tomography (CT) is a widely used diagnostic tool for patients with pelvic fractures. In this pilot study, we hypothesized that pelvic hematoma volumes derived using a rapid automated deep learning-based quantitative visualization and measurement algorithm predict interventions and outcomes including (a) need for angioembolization (AE), pelvic packing (PP), or massive transfusion (MT), and (b) in-hospital mortality. METHODS We performed a single-institution retrospective analysis of 253 patients with bleeding pelvic fractures who underwent admission abdominopelvic trauma CT between 2008 ...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: ORIGINAL ARTICLES Source Type: research
Introduction: The ketogenic diet (KD) is an effective therapeutic option for patients with drug-resistant epilepsy (DRE) and is the only therapy currently available for Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS). Careful monitoring by the nutritional team is required, especially in the first few months of therapy, to check adherence to the diet, adjust the menus to nutritional requirements and investigate possible side effects. Nutritional and dietetic monitoring is usually conducted during control visits, but can be integrated by e-mail.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Medicinal cannabinoid use continues to evolve across the United States, although legitimate federal recognition for medicinal purpose is lacking. Variability exists across states within the United States with respect to legislation, and health care institutions encounter challenges when patients present with a history of medicinal cannabinoid use. Emerging evidence in the field of neurosciences suggests a role of cannabinoids for neurologic medical conditions such as Parkinson disease, multiple sclerosis, and epilepsy. We aim to provide an overview of cannabinoids including a historical perspective, pharmacology, applicati...
Source: Critical Care Nursing Quarterly - Category: Nursing Tags: Original Articles Source Type: research
ConclusionsThe findings of this study indicate the need to devote more attention to family and peer influences on an individual's behaviour by policymakers, in developing preventive strategies. As well as, the need to raise the awareness of individuals in the society about drug use, subsequently, changes their incorrect perceptions towards drugs through several strategies including educational programmes as well as workshops whether in school, universities or social media.
Source: Journal of Pharmaceutical Health Services Research - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
Publication date: Available online 21 February 2020Source: NeuroscienceAuthor(s): Stefania Beretta, Laura Gritti, Chiara Verpelli, Carlo SalaAbstractTwo major processes tightly regulate protein synthesis, the initiation of mRNA translation and elongation phase that mediates the movement of ribosomes along the mRNA. The elongation phase is a high energy-consuming process, and it is mainly regulated by the eukaryotic elongation factor 2 kinase (eEF2K) activity that phosphorylates and inhibits eEF2, the only known substrate of the kinase. Several signaling pathways closely regulate the activity of eEF2K because the translatio...
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 21 February 2020Source: NeuroscienceAuthor(s): Diana C. Rotaru, Edwin J. Mientjes, Ype ElgersmaAbstractThe UBE3A gene is part of the chromosome 15q11-q13 region that is frequently deleted or duplicated, leading to several neurodevelopmental disorders. Angelman syndrome (AS) is caused by the absence of functional maternally derived UBE3A protein, while the paternal UBE3A gene is present but silenced specifically in neurons. Patients with AS present with severe neurodevelopmental delay, with pronounced motor deficits, absence of speech, intellectual disability, epilepsy, and sleep problems....
Source: Neuroscience - Category: Neuroscience Source Type: research
Tozuda, a company based in Philadelphia, has developed a head impact sensor that can be attached to a sports helmet, such as those worn by football or hockey players, and which will indicate if a dangerous impact has occurred. The sensor undergoes a ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Neurology Sports Medicine Source Type: blogs
Publication date: 1 July 2020Source: Personality and Individual Differences, Volume 160Author(s): Aisha J.L. Munk, Norina M. Schmidt, Juergen HennigAbstractImpulsivity is regarded as a personality dimension that is associated with fast acting without always thinking of its consequences. Whereas it has been associated with a lot of pathologies, its neural associations and in which way these are related to motivational- and incentive salience, are far from being clear. Furthermore, sex differences suggest some associations with different reactivity across the menstrual cycle in women, hinting to possible hormonal influences....
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 21 February 2020Source: SeizureAuthor(s): Katharina Mahr, Marc-Philipp Bergmann, Lara Kay, Leona Möller, Philipp S. Reif, Laurent M. Willems, Katja Menzler, Susanne Schubert-Bast, Karl Martin Klein, Susanne Knake, Felix Rosenow, Johann Philipp Zöllner, Adam StrzelczykABSTRACTPurposeMost patients who die from sudden unexpected death in epilepsy (SUDEP) are found in the prone position. We evaluated whether changes in body position occur during generalized convulsive seizures (GCSs).MethodGCSs in patients undergoing video-EEG-monitoring between 2007 and 2017 at epilepsy centers in ...
Source: Seizure - Category: Neurology Source Type: research
Publication date: April 2020Source: Epilepsy &Behavior, Volume 105Author(s): Gagandeep Singh, Josemir W. SanderAbstractThe Global Burden of Epilepsy Report estimates that there are 13 million disability adjusted life years due to epilepsy each year. Estimates of years lived with disability attributed to uncontrolled and untreated epilepsies are particularly raised in comparison to controlled epilepsies in countries with low sociodemographic indices. There are 50 million people with epilepsy in the world and of these, 125,000 die each year, and over 80% of these deaths occur in low- and middle-income countries. Overall,...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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