Cancers, Vol. 12, Pages 247: Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma

Cancers, Vol. 12, Pages 247: Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma Cancers doi: 10.3390/cancers12010247 Authors: Amanda Meneses Ferreira Lacombe Iberê Cauduro Soares Beatriz Marinho de Paula Mariani Mirian Yumie Nishi João Evangelista Bezerra-Neto Helaine da Silva Charchar Vania Balderrama Brondani Fabio Tanno Victor Srougi José Luiz Chambo Ricardo Miguel Costa de Freitas Berenice Bilharinho Mendonca Ana O. Hoff Madson Q. Almeida Isabel Weigand Matthias Kroiss Maria Claudia Nogueira Zerbini Maria Candida Barisson Villares Fragoso Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an unfavorable prognosis. Despite the poor prognosis in the majority of patients, no improvements in treatment strategies have been achieved. Therefore, the discovery of new prognostic biomarkers is of enormous interest. Sterol-O-acyl transferase 1 (SOAT1) is involved in cholesterol esterification and lipid droplet formation. Recently, it was demonstrated that SOAT1 inhibition leads to impaired steroidogenesis and cell viability in ACC. To date, no studies have addressed the impact of SOAT1 expression on ACC prognosis and clinical outcomes. We evaluated SOAT1 expression by quantitative real-time polymerase chain reaction and immunohistochemistry in a tissue microarray of 112 ACCs (Weiss score ≥ 3) from adults treated in a single tertiary center in Brazil. Two independent pathologists evalu...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research