Cancers, Vol. 12, Pages 247: Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma
Cancers, Vol. 12, Pages 247: Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma
Cancers doi: 10.3390/cancers12010247
Authors:
Amanda Meneses Ferreira Lacombe
Iberê Cauduro Soares
Beatriz Marinho de Paula Mariani
Mirian Yumie Nishi
João Evangelista Bezerra-Neto
Helaine da Silva Charchar
Vania Balderrama Brondani
Fabio Tanno
Victor Srougi
José Luiz Chambo
Ricardo Miguel Costa de Freitas
Berenice Bilharinho Mendonca
Ana O. Hoff
Madson Q. Almeida
Isabel Weigand
Matthias Kroiss
Maria Claudia Nogueira Zerbini
Maria Candida Barisson Villares Fragoso
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an unfavorable prognosis. Despite the poor prognosis in the majority of patients, no improvements in treatment strategies have been achieved. Therefore, the discovery of new prognostic biomarkers is of enormous interest. Sterol-O-acyl transferase 1 (SOAT1) is involved in cholesterol esterification and lipid droplet formation. Recently, it was demonstrated that SOAT1 inhibition leads to impaired steroidogenesis and cell viability in ACC. To date, no studies have addressed the impact of SOAT1 expression on ACC prognosis and clinical outcomes. We evaluated SOAT1 expression by quantitative real-time polymerase chain reaction and immunohistochemistry in a tissue microarray of 112 ACCs (Weiss score ≥ 3) from adults treated in a single tertiary center in Brazil. Two independent pathologists evalu...
Source: Cancers - Category: Cancer & Oncology Authors: Amanda Meneses Ferreira Lacombe Iber ê Cauduro Soares Beatriz Marinho de Paula Mariani Mirian Yumie Nishi Jo ão Evangelista Bezerra-Neto Helaine da Silva Charchar Vania Balderrama Brondani Fabio Tanno Victor Srougi Jos é Luiz Chambo Ricardo Miguel Cost Tags: Article Source Type: research
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