GSE110680 Inhibiting WNT and NOTCH in renal cancer stem cells: implications for human patients

Contributors : Annika Fendler ; Kun Son ; Wei Chen ; Walter BirchmeierSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe detected and characterized CXCR4+MET+CD44+ cancer stem cells (CSCs) that were quantitatively correlated with aggressive tumors. Transcriptional profiling and single-cell sequencing revealed a strong activation of WNT and NOTCH signaling in these CSCs. CEL-Seq was performed to study heterogeneity of the CXCR4+MET+CD44+ population.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research