Bisphenol A exposure is involved in the development of Parkinson like disease in Drosophila melanogaster.

Bisphenol A exposure is involved in the development of Parkinson like disease in Drosophila melanogaster. Food Chem Toxicol. 2020 Jan 14;:111128 Authors: Musachio EAS, Araujo SM, Bortolotto VC, de Freitas Couto S, Dahleh MMM, Poetini MR, Jardim EF, Meichtry LB, Ramborger BP, Roehrs R, Petri Guerra G, Prigol M Abstract The pathogenesis of Parkinson's disease has not been fully clarified yet but its cause is known to be multifactorial. One of these factors is oxidative stress induced by exposure to environmental toxifiers. We studied the effect of Bisphenol A (BPA) at concentrations of 0.5 mM and 1 mM, the concentration of 1 mM corresponding to Lowest Observed Adverse Effect Level (LOAEL) for humans in adult Drosophila melanogaster. The BPA induced oxidative stress was established by increased levels of malondialdehyde, reactive species, and decreased activity of the antioxidant enzymes superoxide dismutase and catalase, and detoxificant enzyme glutathione-S-transferase. Associated with oxidative stress, there was a reduction of acetylcholinesterase activity and a reduction of dopamine levels, which are related to the decreased locomotion activity as observed in negative geotaxis, open field and equilibrium behaviors in group exposed to 1 mM of BPA. Oxidative stress also impaired mitochondrial and cellular metabolic activity in the head causing an increase in the mortality of flies exposed to both BPA concentrations. Therefore,...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research