Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers

ConclusionsOur findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted.
Source: Molecular Autism - Category: Molecular Biology Source Type: research

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Abstract Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highlight the impact of SARS-CoV-2 (the coronavirus causing COVID-19) on the central nervous system as there is an urgent need to understand the longitudinal impacts of COVID-19 on brain function, behaviour and cognition. Furthermore, we address the possibility of intergenerational impacts of COVID-19 on the brain, potentially via both maternal and paternal routes. Evidence from preclinical models of earlier coronaviruses has shown direct viral infiltration across the blood-brain bar...
Source: The Australian and New Zealand Journal of Psychiatry - Category: Psychiatry Authors: Tags: Aust N Z J Psychiatry Source Type: research
CONCLUSION: In this context, preventive measures and specialized care are necessary. Thus, it is important to propose a close follow-up to the individuals who have been infected by the virus, in order to set up the earliest care possible. Likewise, in pregnant women, screening of mood disorders during the pregnancy or the postpartum period must be facilitated. The follow-up of the babies born during the pandemic must be strengthened to screen and care for possible neurodevelopmental disorders. PMID: 32928535 [PubMed - as supplied by publisher]
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
CONCLUSION: Lower maternal postpartum plasma LDL concentration was associated with increased odds of ASD in offspring among children born to overweight and obese mothers. Our findings suggest that both maternal BMI and lipids should be considered in assessing their role in offspring ASD risk; and additional longitudinal studies are needed to better understand maternal lipid dynamics during pregnancy among normal weight and overweight/obese mothers. PMID: 32919032 [PubMed - as supplied by publisher]
Source: Annals of Epidemiology - Category: Epidemiology Authors: Tags: Ann Epidemiol Source Type: research
Children exposed to the influenza A(H1H1)pdm09 vaccine in utero were no more likely to develop autism than children whose mothers were not vaccinated during pregnancy, a study has found.Medscape Medical News
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Pediatrics News Source Type: news
DiscussionThis umbrella review of associations between maternal prenatal use of analgesic drugs and children ’s neurodevelopmental disorders could allow for firmer conclusions to be drawn through the synthesis of all relevant published research. The synthesis of findings using high-quality evidence could provide more accurate healthcare information on the long-term effects of analgesic drugs on neurodeve lopment, to better guide future clinical decisions during pregnancy. This review will also allow gaps and methodological differences in the literature to be identified, informing recommendations for future research.S...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Abstract Polyunsaturated fatty acids (PUFAs) are critical for brain development and have been linked with neurodevelopmental outcomes. We conducted a population-based case control study in California to examine the association between PUFAs measured in mid-pregnancy serum samples and child autism spectrum disorder (ASD). ASD cases (n = 499) were identified through the Department of Developmental Services and matched to live-birth population controls (n = 502) on birth month, year (2010-2011), and sex. Crude and adjusted logistic regression models were used to examine associations. Secondary ana...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
TUESDAY, Sept. 1, 2020 -- Maternal influenza A(H1N1)pdm09 vaccination during pregnancy is not associated with risk for autism spectrum disorder (ASD) in offspring, according to a study published online Sept. 1 in the Annals of Internal...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
TUESDAY, Sept. 1, 2020 -- Pregnant women are understandably worried about everything that goes into their bodies. But here's one worry they can cross off that list: flu shots. A large, new study has confirmed that an expectant woman's flu shot...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Researchers from the Karolinska Institutet in Stockholm, Sweden, studied birth records of 69,000 children born between 2009 and 2010 and found autism was lower in the vaccine group.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSION: This large cohort study found no association between maternal H1N1 vaccination during pregnancy and risk for ASD in the offspring. PRIMARY FUNDING SOURCE: Swedish Research Council. PMID: 32866418 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
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