Omega-3 fatty acids in contrast to omega-6 protect against pneumococcal pneumonia

ConclusionsSupplementation of mouse diets with Omega-3 fatty acids improved survival, bacterial invasion in the blood and lungs as well as decreased overall lung tissue inflammation and cell death when compared to the Omega-6 supplemented diets. Translation of these findings in humans may improve outcomes of patients at risk for pneumonia.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research

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ConclusionsMost KS-ILD patients showed a tendency for chronic disease onset and long-term stabilization of pulmonary function.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Empirical anti-MRSA treatment is associated with an increased risk of 30-day mortality in patients hospitalized for pneumonia, compared with standard antibiotic therapy, according to a retrospective study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Pulmonary Medicine News Source Type: news
Authors: Lim J, Jeon S, Shin HY, Kim MJ, Seong YM, Lee WJ, Choe KW, Kang YM, Lee B, Park SJ PMID: 32080993 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Authors: Kim JY PMID: 32080992 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
BACKGROUND As nonoperative management (NOM) of blunt splenic injury (BSI) increases, understanding risks, especially infectious complications, becomes more important. There are no national studies on BSI outcomes that track readmissions across hospitals. Prior studies demonstrate that infection is a major cause of readmission after trauma and that a significant proportion is readmitted to different hospitals. The purpose of this study was to compare nationwide outcomes of different treatment modalities for BSI including readmissions to different hospitals. METHODS The Nationwide Readmissions Database for 2010 to 2014 ...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: ORIGINAL ARTICLES Source Type: research
CONCLUSION Admission location of stable patients with isolated mild to moderate abdominal SOIs is variable across hospitals, but hospitalization at a facility with greater ICU use is not associated with substantially improved outcomes. LEVEL OF EVIDENCE Therapeutic/care management, Level IV.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: ORIGINAL ARTICLES Source Type: research
Publication date: Available online 20 February 2020Source: Microbes and InfectionAuthor(s): Xingchen Pan, David M. Ojcius, Tianyue Gao, Zhongsheng Li, Chunhua Pan, Chungen PanAbstractOnly a month after the outbreak of pneumonia caused by 2019-nCoV, more than forty-thousand people were infected. This put enormous pressure on the Chinese government, medical healthcare provider, and the general public, but also made the international community deeply nervous. On the 25th day after the outbreak, the Chinese government implemented strict traffic restrictions on the area where the 2019-nCoV had originated—Hubei province, w...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 20 February 2020Source: Acta Pharmaceutica Sinica BAuthor(s): Kudelaidi Kuerban, Xiwen Gao, Hui Zhang, Jiayang Liu, Mengxue Dong, Lina Wu, Ruihong Ye, Meiqing Feng, Li YeAbstractMore efficient drug delivery system and formulation with less adverse effects are needed for the clinical application of broad-spectrum antineoplastic agent doxorubicin (DOX). Here we obtained outer-membrane vesicles (OMVs), a nano-sized proteoliposomes naturally released by Gram-negative bacteria, from attenuated Klebsiella pneumonia and prepared doxorubicin-loaded OMVs (DOX-OMV). Confocal microscopy and in vivo ...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
PMID: 32075859 [PubMed - in process]
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Eur Respir Rev Source Type: research
rtado D, Torres A Abstract Very old (aged ≥80 years) adults constitute an increasing proportion of the global population. Currently, this subgroup of patients represents an important percentage of patients admitted to the intensive care unit. Community-acquired pneumonia (CAP) frequently affects very old adults. However, there are no specific recommendations for the management of critically ill very old CAP patients. Multiple morbidities, polypharmacy, immunosenescence and frailty contribute to an increased risk of pneumonia in this population. CAP in critically ill very old patients is associated with higher...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Eur Respir Rev Source Type: research
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