GSE124617 Functional and Topographic Effects on DNA Methylation Across IDH1/2 Mutant Cancers
Conclusions: We show that there are gene region and chromosome specific areas that are preferentially affected or spared by changes in DNA methylation across IDH mutant cancers. This suggests that while IDH mutation causes the same biochemical change in all cancers, the effect may vary in tissue specific fashion. Hypomethylation of enhancers associated with cell differentiation may mediate lack of differentiation in IDH1/2mutant cancers.
HEART disease: Around twice as many people are living with heart and circulatory diseases in the UK than with cancer and Alzheimer's disease combined according to the British Heart Foundation. Could a seemingly innocent and popular drug be contributing to these shocking statistics?
AbstractGasdermins (GSDM) are members of a family of pore-forming effector proteins which lead to membrane permeabilization and pyroptosis, a lytic cell death with pro-inflammatory characteristics. Recently, two members of the gasdermin family, gasdermin B (GSDMB) and gasdermin E (GSDME), were shown to suppress tumor growth, through the involvement of cytotoxic lymphocytes. Other studies also reported the important functions of gasdermins in various cancer types including gastric cancer, hepatocarcinoma, and cervix and breast cancer. However, gasdermins have not been previously studied in the context of serous ovarian canc...
This study provides pilot data for the further development ofL. casei exoproducts as an anti-inflammatory or anti-proliferative agent for the treatment of inflammatory and cancer diseases in gut. However, more data is needed before final conclusions ofL. casei cell-free supernatant ’s efficacy can be drawn.
More than two in five (42%) teaching assistants, caretakers, cleaners and other school support staff in England and Wales are actively looking for better paid jobs because of the rising cost of living and persistent low pay in education, according to a UNISON survey released today (Friday). The survey responses paint a bleak picture of school employees living with no heating or hot water because of broken boilers they can’t afford to fix, worrying about how to pay for dental treatment, relying on their children for money, or going to food banks. The findings reveal an overwhelming majority (96%) say the r...
Health care costs in the U.S. have increased dramatically over the past five decades, from $74 billion in 1970 to $3.8 trillion in 2019. This trend has been fueled in large part by an increase in the number of people who struggle with chronic conditions such as cancer, diabetes, hypertension, and lung disease. Stanford UniversityRead more …How advanced analytics can help social determinants of health originally appeared inKevinMD.com.
Lab Chip, 2021, Advance Article DOI: 10.1039/D1LC00801C, PaperHyeono Nam, Hyung Jin Sung, Jinsoo Park, Jessie S. Jeon TSAWs quickly form a tumor spheroid for a drug screening platform. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Rout searched everywhere for a thoughtfully designed, stylish pill case to keep her medication and was disappointed to find plastic, highly medical options on the market. "In a world where you can buy almost anything online, it made me feel both as a consumer and a human being completely forgotten"
Although advancements in cervical cancer prevention have helped reduce the incidence, mortality, and prevalence, access to these preventive services has not been experienced equally by all women in the United States. The purpose of this study was to learn about the factors that affect access to preventive services in a low-income, primarily Black community. Using a community-based participatory research approach, women were recruited to participate in 7 focus groups, with 6 to 8 women per group (N = 45). Participants were mainly Black (64%), with a mean age of 46 years, and 60% reporting completing at least some college. T...
Women with newly diagnosed ovarian cancer and a BRCA mutation see sustained benefits in progression free survival rates after two years of maintenance olaparib therapy, a clinical trial analysis suggests.Reuters Health Information