High homogeneity of MMR deficiency in ovarian cancer.

CONCLUSIONS: Our data show that MSI is present in a substantial proportion of endometrioid ovarian cancers but can also occur in other tumor subtypes. MMR deficiency/MSI typically involves the entire tumor mass, suggesting that MMR inactivation occurs early in tumorigenesis in a subset of ovarian cancers. PMID: 31924330 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31924330?dopt=Abstract

Source: Gynecologic Oncology - January 6, 2020 Category: Cancer & Oncology Authors: Fraune C, Rosebrock J, Simon R, Hube-Magg C, Makrypidi-Fraune G, Kluth M, Büscheck F, Höflmayer D, Schmalfeldt B, Müller V, Wölber L, Witzel I, Paluchowski P, Wilke C, Heilenkötter U, von Leffern I, Clauditz TS, Wilczak W, Sauter G, Steurer S, Burand Tags: Gynecol Oncol Source Type: research