Rapid Assessment of Opioid Exposure and Treatment in Cities Through Robotic Collection and Chemical Analysis of Wastewater.

CONCLUSION: Wastewater-based epidemiology with smart sewer selection and robotic wastewater collection is feasible to detect the presence of specific opioids, naloxone, methadone, and buprenorphine within a city. These results suggest that wastewater epidemiology could be used to detect patterns of opioid exposure and may ultimately provide information for opioid use disorder (OUD) treatment and harm reduction programs. PMID: 31919800 [PubMed - as supplied by publisher]
Source: Journal of Medical Toxicology - Category: Toxicology Authors: Tags: J Med Toxicol Source Type: research

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The rates of opioid overdose in the United States quadrupled between 1999 and 2017, reaching a staggering 130 deaths per day. This health epidemic demands innovative solutions that require uncovering the key brain areas and cell types mediating the cause of overdose — opioid-induced respiratory depression. Here, we identify two primary changes to murine breathing after administering opioids. These changes implicate the brainstem's breathing circuitry which we confirm by locally eliminating the µ-Opioid receptor. We find the critical brain site is the preBöt zinger Complex, where the breathing rhythm origin...
Source: eLife - Category: Biomedical Science Tags: Human Biology and Medicine Neuroscience Source Type: research
OBJECTIVE: Drug overdoses among men have historically outnumbered those among women by a large margin. Yet, U.S. research on the first wave of the opioid epidemic involving prescription opioids has found women to be at increased risk. The current study con...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
CONCLUSIONS: Overdose deaths seem to have returned to a historically familiar pattern of dominance by younger males. Our findings suggest the gender-age distribution in deaths to specific opioid types must be considered for effective intervention. PMID: 32048603 [PubMed - in process]
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
New largescale study in the American Journal of Preventive Medicine found overprescription of opioids by dentists common, particularly to patients at high risk for substance abuse, and that almost 1/3 of patients received more powerful drugs than neededElsevierIMAGE: In this cross-sectional analysis of 542,958 dental visits by adult patients, between 1 in 4 and 1 in 2 opioid prescriptions exceeded the recommended morphine equivalents and days'supply for...viewmore Credit: Michelle S. Woods Ann Arbor, February 4, 2020 - Dentists are among top prescribers of opioids in the US, however, whether their opioid prescrib...
Source: Dental Technology Blog - Category: Dentistry Source Type: news
BOSTON (AP) — Massachusetts health officials said Wednesday the rate of opioid-related overdose deaths in the state fell an estimated 5% from its 2016 peak. The decline comes despite the growing presence of the synthetic opioid fentanyl as a driver of opioid-related overdose deaths, according to the Massachusetts Department of Public Health. In 2019, the opioid-related overdose death rate was 29 per 100,000 people. In 2016, it was 30.5 per 100,000 people. According to the report, there were 2,023 confirmed and estimated opioid-related overdose deaths in 2019. For the same period in 2016, there were 2,097 confirmed op...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health opioid crisis opioids Source Type: news
MONDAY, Feb. 10, 2020 -- In the midst of a U.S. epidemic of opioid abuse, knowing how to quickly administer the anti-overdose drug naloxone could save a life. Now, research finds that delivering naloxone via nasal spray could be the quickest and...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
If you were to sum up the overall health of a nation in one single number, what would that be? At the top of the list, you would likely find average life expectancy — the total number of years, on average, that a person in a country can expect to live. Wars, famine, and economic crises are expected to lower life expectancy. Breakthroughs in science, strong economies, and behaviors like eating a healthy diet, exercising, and avoiding tobacco typically raise average life expectancy. An amazing rise, a surprising fall Between 1959 and 2014, the United States experienced an unprecedented increase in life expectancy, whic...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Health Health care disparities Men's Health Women's Health Source Type: blogs
Deaths involving fentanyl analogs, such as carfentanil, have increased the severity of the opioid overdose epidemic in Florida.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Cause of death MMWR Morbidity & Mortality Weekly Report Opioids Source Type: news
Emergency rooms across the United States regularly treat patients with opioid use disorder and patients experiencing opioid overdose. Four to six million people in the US are estimated to have opioid use disorder. Over half of overdose related deaths in 2016 resulted from the use of opioids. The majority of deaths involved the use of fentanyl. There is an opioid epidemic plaguing the nation and with emergency rooms at the forefront of the proverbial battlefield; they can potentially play a key role in addressing the problem.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research
The opioid overdose epidemic kills about 130 people a day in the United States and it is estimated that there are about 2.1 million people who suffer from an opioid use disorder (OUD). Academic neuroscientists, psychiatrists and the National Institute of Drug Abuse have spent the last forty-years establishing the foundation of addiction as a brain disorder. It is now clear that extended opioid use causes multiple important and at times, irreversible changes to the brain, especially to its dopamine and opioid systems.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research
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