The role of Annexin A1 and formyl peptide receptor 2/3 signaling on chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory.

CONCLUSION: In conclusion, the absence of the ANXA1 protein, even more than the absence of its main receptor (FPR 2/3), was fundamental to the inhibitory action of GC on the HPA axis; it also maintained the hippocampal homeostasis by preventing neuronal damage associated with depression.
PMID: 31914916 [PubMed - as supplied by publisher]

Source: CNS and Neurological Disorders Drug Targets - January 5, 2020 Category: Drugs & Pharmacology Authors: Peritore AF, Crupi R, Scuto M, Gugliandolo E, Siracusa R, Impellizzeri D, Cordaro M, D'amico R, Fusco R, Di Paola R, Cuzzocrea S Tags: CNS Neurol Disord Drug Targets Source Type: research