Maternal Butalbital Use and Selected Defects in the National Birth Defects Prevention Study.

CONCLUSIONS: We observed relationships between maternal periconceptional butalbital use and certain congenital heart defects. These associations have not been reported before, and some may be spurious. Butalbital use was rare and despite the large size of the National Birth Defects Prevention Study, the number of exposed case and control infants was small. However, if confirmed in additional studies, our findings will be useful in weighing the risks and benefits of butalbital for the treatment of migraine and tension-type headaches.
PMID: 24001268 [PubMed - as supplied by publisher]

Source: Headache - September 3, 2013 Category: Neurology Authors: Browne ML, Van Zutphen AR, Botto LD, Louik C, Richardson S, Druschel CM Tags: Headache Source Type: research