Comparison of different kinetic models for dynamic 18F-FDG PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function.

Comparison of different kinetic models for dynamic 18F-FDG PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function. Phys Med Biol. 2020 Jan 02;: Authors: Geist BK, Wang J, Wang X, Lin J, Yang X, Zhang H, Li F, Zhao H, Hacker M, Huo L, Li X Abstract A kinetic modeling analysis was performed on hepatocellular carcinoma (HCC) as well as healthy liver tissue regions from dynamic FDG positron emission tomography s/ computer tomography (PET/CT) cans. On basis of image derived input function from hepatic artery and portal vein, various kinetic models were compared among each other in order to check whether HCC can be classified and differ from healthy tissue within the kinetic parameters. 14 HCC and 10 healthy liver regions from FDG PET/CT scans of 10 patients were analyzed from their time activity curves (TACs) were extracted from the PET dynamic images. Also the hepatic artery and the portal vein were delineated in the fused PET/CT images, which were used as input functions. Four kinetic models were applied to the TACs, using both or only one input function. Results were analyzed with several information criteria according to Akaike and Schwartz as well as be the F-Test. The paired student's t-test was used to determine the differences between HCC and healthy regions. All applied models revealed significant differences of p
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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We present the case of a 63-year-old patient that was diagnosed in another Clinic with squamous skin carcinoma, but, after complete resection in our Hospital, it was proven to be breast cancer. At diagnosis, computed tomography (CT) scan showed local disease. Adjuvant treatment, consisting in chemotherapy and radiotherapy, was administered. At the beginning of hormonal therapy, the patient had a new CT scan that showed liver and bone metastases. The patient started palliative hormonal treatment with bisphosphonates. The aim of the study was to highlight both the importance of early diagnosis and treatment and the aggressiv...
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