1123: Diet-induced obesity aggravates preeclampsia-like phenotypes in ASB4-null mice

In the past three decades, the incidence of preeclampsia, characterized by hypertension, proteinuria and end organ damage, has significantly increased in the U.S., in association with an increase in maternal weight. There is a gap in our understanding regarding how obesity influences preeclampsia. Ankiryn-repeat-and-SOCS-box-containing-protein 4 (ASB4) contributes to the differentiation of trophoblast stem cells into the giant trophoblast cells necessary for embryo implantation in mice. ASB4-null females develop preeclampsia-like phenotypes during pregnancy.

Source: American Journal of Obstetrics and Gynecology - December 31, 2019 Category: OBGYN Authors: Feng Li, Neeta L. Vora, Kim Boggess, Nobuyo Maeda-Smithies Tags: Poster Session V Source Type: research