ROR2 induces cell apoptosis via activating IRE1 α/JNK/CHOP pathway in high-grade serous ovarian carcinoma in vitro and in vivo

Epithelial ovarian cancer (EOC) is the most lethal cancer in female genital tumors. New disease markers and novel therapeutic strategies are urgent to identify considering the current status of treatment. Rece...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research

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Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial cancers are primarily imported from either endometrial or fallopian tube epithelium. The prevailing paradigm in the genesis of high-grade serous carcinoma (HGSC), the most common ovarian cancer, posits development in fallopian tubes through stepwise tumor progression. In recent years, progress has been made not only in gathering terabytes of omics data but also in detailing the histologic-molecular correlations required to look into and make sense of the tissue origin of HGSC.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research
Abstract Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial cancers are primarily imported from either endometrial or fallopian tube epithelium. The prevailing paradigm in the genesis of high-grade serous carcinoma (HGSC), the most common ovarian cancer, posits development in fallopian tubes through stepwise tumor progression. In recent years, progress has been made not only in gathering terabytes of omics data but also in detailing the histologic-molecular correlations required to look into and make sense of the tissue origin of HGSC. This emerging paradigm is changing many ...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
This study shows that the RECAP test is an attractive alternative to DNA-based HRD tests, and further development of a clinical grade RECAP test is clearly warranted.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Ovarian cancer is the most lethal gynecologic malignancy. Early detection would improve survival, but an effective diagnostic test does not exist. Novel biomarkers for early ovarian cancer diagnosis are therefore warranted. We performed intraoperative blood sampling from ovarian veins of stage I epithelial ovarian carcinomas and analyzed the serum proteome. Junction plakoglobin (JUP) was found to be elevated in venous blood from ovaries with malignancies when compared to those with benign disease. Peripheral plasma JUP levels were validated by ELISA in a multicenter international patient cohort. JUP was significantly incre...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Zarychta E, Lepinay K, Szubert S, Jozwicki J, Misiak J, Brozyna A, Kosinska-Kaczynska K, Lewandowska A, Malicka E, Makarewicz A, Rhone P, Jozwicki W Abstract OBJECTIVES: Ovarian cancer is a heterogeneous disease, with a number of different histological subtypes with various responses to treatment. Wilms' tumor 1 (WT1) immunoreactivity is used to distinguish between OC's various subtypes. However, little is known about the protein's role as a prognostic factor. Thus, the main aim of our study was to evaluate the relationship between WT1 expression and patient overall survival (OS) and lymph node metastases....
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
Abstract High-grade serous ovarian carcinoma (HGSOC) is one of the most common ovarian epithelial carcinomas. It is highly invasive, easily recurs after systemic treatment, and has a poor prognosis. Despite many new chemotherapeutic drugs and trials of combinations of different regimens that have been used in treatment attempts, there has been no meaningful progress in the treatment of HGSOC. With the development of gene sequencing technology, gene therapy has become a new direction for tumors treatment. It's reported that the P53 has a very high mutation rate in HGSOC, which provides a theoretical basis for the a...
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research
S100A4 is a small calcium-binding protein that exerts its biological functions by interacting with nonmuscle myosin IIA (NMIIA) and p53. Although S100A4 promotes metastasis in several tumors, little is known about its involvement in the progression of ovarian high-grade serous carcinomas (HGSCs). Herein, we focused on functional roles of the S100A4/NMIIA/p53 axis in these tumors. In HGSC cell lines harboring mutant p53, knockdown (KD) of S100A4 reduced the expression of several epithelial-mesenchymal transition/cancer stem cell markers and the ALDH1high population, consistent with an inhibition of stemness features.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research
Abstract S100A4 is a small calcium-binding protein that exerts its biological functions by interacting with non-muscle myosin IIA (NMIIA) and p53. Although S100A4 promotes metastasis in several tumors, little is known about its involvement in the progression of ovarian high-grade serous carcinomas (HGSC). Herein, we focused on functional roles of the S100A4/NMIIA/p53 axis in these tumors. In HGSC cell lines harboring mutant p53 (p53mt), knockdown (KD) of S100A4 reduced the expression of several epithelial-mesenchymal transition (EMT) /cancer stem cell (CSC) markers and the ALDH1high population, consistent with an ...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
S100A4 is a small calcium-binding protein that exerts its biological functions by interacting with non-muscle myosin IIA (NMIIA) and p53. Although S100A4 promotes metastasis in several tumors, little is known about its involvement in the progression of ovarian high-grade serous carcinomas (HGSC). Herein, we focused on functional roles of the S100A4/NMIIA/p53 axis in these tumors. In HGSC cell lines harboring mutant p53 (p53mt), knockdown (KD) of S100A4 reduced the expression of several epithelial-mesenchymal transition (EMT) /cancer stem cell (CSC) markers and the ALDH1high population, consistent with an inhibition of &lsq...
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research
High-grade serous ovarian carcinoma (HGSOC) usually spreads directly into the peritoneal cavity following a transcoelomic dissemination route, although distant hematogenous metastasis exist and have been reported. However, no tumor markers can currently predict the risk of distant metastases in HGSOC. Claudins, belonging to tight-junction proteins, are dysregulated in HGSOC and functionally related to cancer progression. Here we analyzed claudin-3, -4, and -7 expression as potential markers of distant metastases. Using quantitative RT-PCR and immunohistochemistry we assessed the expression of claudins in primary HGSOC tiss...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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