Association of expression of p53, Livin, ERCC1, BRCA1 and PARP1 in Epithelial Ovarian Cancer tissue with Drug Resistance and Prognosis

ConclusionsThe elevated expression levels of ERCC1 and BRCA1 were identified as significant risk factors for chemo-resistance in EOC. Reduced expression levels of ERCC1, BRCA1 and PARP1 were significantly associated with better overall survival. The CA125 levels were significantly higher in patients with EOC specimens that were positive of p53, BRCA1, ERCC1 and Livin.
Source: Pathology Research and Practice - Category: Pathology Source Type: research