An atomic view of the trigger for the heartbeat

(University of Washington Health Sciences/UW Medicine) Tiny pores in heart cells generate electrical signals to initiate each heart beat. Structural studies of these channels provide details on their functions, and also on their malfunction due to different inherited mutations. These include ones behind sudden death in young athletes. Information on the architecture and mechanics of cardiac sodium channels could help develop better diagnostics and medications for life-threatening heart arrhythmia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusions: The clinical antiarrhythmic mechanisms of DFD are based on its antioxidant potential, alleviation of Na+-K+-ATPase and connexin-43, and class I antiarrhythmic properties by suppressing Nav1.5dose-dependently with an IC50 of 24.0 ± 2.4 mg/mL. PMID: 32256664 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Song Z, Gao R, Yan B Abstract Cardiovascular disease is still the main cause of morbidity and mortality worldwide. Currently, the frontier of research into cardiovascular disease is the field of non-coding RNA. In this review, information was collected on the use of micro-RNAs as non-invasive biomarkers and their role in pathophysiological processes and therapeutic applications. In the case of microRNA-1 and microRNA-133, the roles and regulatory mechanisms of them are reviewed for arrhythmia, myocardial infarction, diabetic cardiomyopathy, myocardial hypertrophy, cardiomyocyte differentiation, and cell re...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
This study aimed to ascertain whether tiotropium/olodaterol (T/O) 5/5 μg fixed-dose combination (FDC) may modulate the risk of main cardiovascular outcomes in COPD patients enrolled in randomized controlled trials (RCTs). A meta-analysis (CRD42017070100) was performed by selecting RCTs reporting raw data from the ClinicalTrials.gov database concerning the impact of T/O 5/5 µg FDC vs. monocomponents on the occurrence of specific cardiovascular serious adverse events: arrhythmia, heart failure, myocardial infarction, and stroke. Data were reported as relative risk and 95% Confidence Interval, and the r...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Authors: Martignani C, Massaro G, Biffi M, Ziacchi M, Diemberger I Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia; its incidence is expected to rise in the coming years due to the aging of the western population. It is associated not only with clinical, but also with significant social and economic issues; in fact, AF-related healthcare costs have been estimated at several million euros in some European countries. Therefore, interventions aimed at improvement of clinical management and reduction of direct and indirect healthcare costs, related to AF, would be strongly recommended in view ...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Publication date: June 2020Source: Molecular Genetics and Metabolism Reports, Volume 23Author(s): Shahram Yazdani, Anish Badjatiya, Naghmeh Dorrani, Hane Lee, Wayne W. Grody, Stanley F. Nelson, Katrina M. Dipple
Source: Molecular Genetics and Metabolism Reports - Category: Genetics & Stem Cells Source Type: research
Most common sustained post-operative arrhythmia – MCQ Most common sustained post-operative arrhythmia: a) Atrial tachycardia b) Atrial fibrillation c) Ventricular tachycardia d) Ventricular fibrillation Post your answer as a comment below
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
Commonest cause of SCD due to cardiac arrhythmia – MCQ – Answer Commonest cause of sudden death due to cardiac arrhythmia – Correct answer: d) Coronary artery disease Though all the rest are primary electrical disorders of the heart with high risk of arrhythmic death, their prevalence is quite low compared to coronary artery disease. Hence ventricular fibrillation secondary to acute myocardial infarction/ischemia and previous myocardial infarction with scar related re-entrant ventricular arrhythmia together contribute a much larger number of sudden arrhythmic deaths in the community. Back to question
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
AbstractMyocarditis is as an important cause of sudden cardiac death (SCD) among athletes. The incidence of SCD ascribed to myocarditis did not change after the introduction of pre-participation screening in Italy, due to the transient nature of the disease and problems in the differential diagnosis with the athlete ’s heart. The arrhythmic burden and the underlying mechanisms differ between the acute and chronic setting, depending on the relative impact of acute inflammation versus post-inflammatory myocardial fibrosis. In the acute phase, ventricular arrhythmias vary from isolated ventricular ectopic beats to compl...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
AbstractAtrial fibrillation (AF) is one of the most prevalent arrhythmias. Myocardial sleeves of the pulmonary vein are critical in the occurrence of AF. Our study aims to investigate the effect of synthetic vascular smooth muscle cells (SMCs) on gap junction proteins in cardiomyocytes. (1) Extraction of vascular SMCs from the pulmonary veins of Norway rats. TGF- β1 was used to induce the vascular SMCs switching to the synthetic phenotype and 18- α-GA was used to inhibit gap junctions of SMCs. The contractile and synthetic phenotype vascular SMCs were cocultured with HL-1 cells; (2) Western blotting was used to ...
Source: Heart and Vessels - Category: Cardiology Source Type: research
After cardiac damage, excessive neurite outgrowth (sympathetic hyperinnervation) can occur, which is related to ventricular arrhythmias/sudden cardiac death. Post-damage reactivation of epicardium causes epicardium-derived cells (EPDCs) to acquire a mesenchymal character, contributing to cardiac regeneration. Whether EPDCs also contribute to cardiac re/hyperinnervation, is unknown.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research
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