Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration.

CONCLUSIONS: A key permissive signal from an unidentified AKT-independent pathway is required for stimulating the neuron-intrinsic growth machinery. Future studies into this complex neuron-intrinsic balancing mechanism involving necessary and permissive signals for axon regeneration is likely to lead to safe and effective regenerative strategies for CNS repair. PMID: 31839616 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31839616?dopt=Abstract

Source: Restorative Neurology and Neuroscience - December 17, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research