Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses

Publication date: Available online 11 December 2019Source: NeuroImageAuthor(s): Kenneth Wengler, Xiang He, Anissa Abi-Dargham, Guillermo HorgaAbstractNeuromelanin-sensitive MRI (NM-MRI) provides a noninvasive measure of the content of neuromelanin (NM), a product of dopamine metabolism that accumulates with age in dopamine neurons of the substantia nigra (SN). NM-MRI has been validated as a measure of both dopamine neuron loss, with applications in neurodegenerative disease, and dopamine function, with applications in psychiatric disease. Furthermore, a voxelwise-analysis approach has been validated to resolve substructures, such as the ventral tegmental area (VTA), within midbrain dopaminergic nuclei thought to have distinct anatomical targets and functional roles. NM-MRI is thus a promising tool that could have diverse research and clinical applications to noninvasively interrogate in vivo the dopamine system in neuropsychiatric illness. Although a test-retest reliability study by Langley et al. using the standard NM-MRI protocol recently reported high reliability, a systematic and comprehensive investigation of the performance of the method for various acquisition parameters and preprocessing methods has not been conducted. In particular, most previous studies used relatively thick MRI slices (∼3 mm), compared to the typical in-plane resolution (∼0.5 mm) and to the height of the SN (∼15 mm), to overcome technical limitations such as specific absorption ra...
Source: NeuroImage - Category: Neuroscience Source Type: research

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Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
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Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
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Source: Journal of Neurological Surgery Part B: Skull Base - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
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Publication date: Available online 21 January 2020Source: NeuroImageAuthor(s): Emma M. Brown, Meghan E. Pierce, Dustin C. Clark, Bruce R. Fischl, Juan E. Iglesias, William P. Milberg, Regina E. McGlinchey, David H. SalatAbstractThe human hippocampus is vulnerable to a range of degenerative conditions and as such, accurate in vivo measurement of the hippocampus and hippocampal substructures via neuroimaging is of great interest for understanding mechanisms of disease as well as for use as a biomarker in clinical trials of novel therapeutics. Although total hippocampal volume can be measured relatively reliably, it is critic...
Source: NeuroImage - Category: Neuroscience Source Type: research
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Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
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