Antimicrobial metabolites from the endophytic fungus Aspergillus versicolor

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Gamal A. Mohamed, Sabrin R.M. Ibrahim, Hani Z. AsfourAbstractTwo new diaryl ether derivatives [aspergillethers A (4) and B (5)] and five known metabolites [(22E,24R)-stigmasta-5,7,22-trien-3-β-ol (1), stigmasta-4,6,8(14),22-tetraen-3-one (2), orcinol (3), and butyrolactones I (6) and VI (7)] were separated from the endophytic fungus Aspergillus versicolor (Aspergillaceae) isolated from the roots of Pulicaria crispa Forssk (Asteraceae) growing in Saudi Arabia. The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and HRESIMS) and by comparison with the literature data. Compounds 4 and 5 were evaluated for their antimicrobial properties towards different microorganisms using a disc diffusion assay. Compound 5 exhibited significant antibacterial capacity towards Staphylococcus aureus, Bacillus cereus, and Escherichia coli with inhibition zone diameters (IZDs) of 14.3, 19.8, and 24.5 mm, respectively, and MICs values of 4.3, 3.7, and 3.9 μg/mL, respectively, compared to ciprofloxacin (MICs 3.1, 2.8, and 3.5 μg/mL, respectively). In addition, compound 5 exhibited prominent antifungal activity towards Candida albicans and Geotrichium candidum (IZDs 15.8 mm and 17.5 mm, respectively) in comparison to that of clotrimazole (IZDs 17.2 mm and 21.4 mm, respectively).Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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We report the synthesis and characterization of some organotin(IV) compounds of N-butyl-N-phenyldithiocarbamate complexes represented as [C4H9SnL2] (1), (CH3)2SnL2] (2), (C4H9)2SnL2] (3), (C6H5)2SnL2] (4)], where L is N-butyl-N-phenyldithiocarbamate. Single crystal X-ray analysis of compounds 2 and 3 showed that they possess five or six coordinate geometry. These compounds were evaluated for their antimicrobial properties against Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus, Candida albicans and Aspergillus flavus, and in-vitro cytotoxic activities against human cer...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Conclusion Starter cultures are an important tool that contributes to ensure the safety of fermented meat products. Indeed, the microorganisms that constitute starter cultures may inhibit or reduce the growth of spoilage and/or pathogenic populations through mechanisms, such as production of certain metabolites or competitive exclusion. Thus, the use of starter cultures may reduce the need for chemical additives, such as nitrites and nitrates. Furthermore, the lower residual levels of nitrates and nitrites detected in fermented meat products inoculated with starter cultures are due to the ability of starters to metabolize...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: 15 August 2018 Source:Journal of Molecular Liquids, Volume 264 Author(s): Nadjet Rezki, Salsabeel A. Al-Sodies, Mouslim Messali, Sanaa K. Bardaweel, Pramod K. Sahu, Fawzia F. Al-blewi, Praveen K. Sahu, Mohamed R. Aouad The discovery of a novel series of task-specific fluorinated pyridinium ionic liquids (TsILs) tagged with Schiff bases is reported using ultrasound-assisted and conventional syntheses. The synthesis required the quaternization of the appropriate pyridine Schiff base, followed by the metathesis of the resulting task-specific halogenated pyridinium ILs. The structures of the ILs were establi...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Abstract Natural extracts (anthocyanins, tannin, anatto, curcuma and olive leaf extracts) were encapsulated within a silica network by acid or base-catalyzed sol-gel methods. The nominal encapsulated contents were between 2.5 and 50wt.-%. The resulting materials were characterized by Fourier transform infrared spectroscopy, diffuse reflectance in the UV region, nitrogen adsorption/desorption porosimetry and small angle X-ray scattering. Encapsulated anthocyanin and tannin afforded inhibition zones between 9-21mm towards Staphylococcus aureus, Escherichia coli, Bacillus cereus, Candida sp. and Aspergillus niger, wh...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research
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Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Tags: Eur J Med Chem Source Type: research
Publication date: Available online 12 November 2016 Source:Saudi Pharmaceutical Journal Author(s): Bouzid Djihane, Nouioua Wafa, Soltani Elkhamssa, De Haro Juan Pedro, Angeles Esteban Maria, Zerroug Mouhamed Mihoub The aerial parts of Helichrysum italicum (Roth) G. Don were subjected to hydrodistillation to obtain essential oils which had been analyzed by gas chromatography and gas chromatography coupled with mass spectrometry and tested for antimicrobial activity against 12 bacteria, two yeasts and four fungi by agar diffusion method. The essential oil yielded 0.44% (v/w) and 67 compounds accounting for 99.24% of the oil...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Abstract In the present study, fifteen novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one (6a-o) derivatives were designed as inhibitor of HIV-1 RT using ligand based drug design approach and in-silico evaluated for drug-likeness properties. Designed compounds were synthesized, characterized and in-vitro evaluated for RT inhibitory activity against wild HIV-1 RT strain. Among the tested compounds, four compounds (6a, 6b, 6j and 6o) exhibited significant inhibition of HIV-1 RT (IC50⩽10μg/ml). All synthesized compounds were also evaluated for anti-HIV-1 activity as well as cytotoxic...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Tags: Bioorg Chem Source Type: research
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