Regulation of hepcidin/iron-signalling pathway interactions by commensal bifidobateria plays an important role for the inhibition of metaflammation-related biomarkers.

CONCLUSION: Commensal bifidobacteria ameliorate metaflammation/inflammatory responses to excessive extracellular LPS, oleate and iron through at least two molecular/signaling mechanisms: i. modulation of interactions of the hepcidin- and iron-signaling pathways via reduction of excess iron; ii. reduction of pro-inflammatory cytokines and hepcidin production through inhibition of the TLR4/NF-kB pathway. This may be a molecular basis by which commensal bifidobacteria enhance intrinsic cellular tolerance against excess consumption of energy-yielding substrates and/or free iron.
PMID: 31810825 [PubMed - as supplied by publisher]

Source: Immunobiology - November 28, 2019 Category: Allergy & Immunology Authors: Ghadimi D, Yoness Hassan MF, Fölster-Holst R, Röcken C, Ebsen M, de Vrese M, Heller KJ Tags: Immunobiology Source Type: research