Longitudinal Impact of Temporary Mechanical Circulatory Support on Durable Ventricular Assist Device Outcomes: An IMACS Registry Propensity Matched Analysis
Patients with advanced heart failure and cardiogenic shock (CS) often require temporary circulatory support (TCS) as a bridge to durable ventricular assist devices (dVAD). We aim to characterize longitudinal outcomes of patients with and without CS.
ConclusionIdentifying predictors of complications may contribute to the indications for VA-ECMO.
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Mortality from acute decompensated heart failure (DHF) remains high despite contemporary therapeutic interventions. Cardiogenic shock indices may be useful in risk-stratifying patients at highest risk for death, need for heart transplantation or durable mechanical support. The aim of this study was to compare a novel hemodynamic parameter, systolic blood pressure/pulmonary capillary wedge pressure (SBP/PCWP), to cardiac power output (CPO) in patients presenting with DHF.
Ventricular Assist devices are essential but challenging therapeutic options for advanced heart failure patients with critical conditions including cardiogenic shock. In such cases, bridge to decision (BTD) strategies using temporary mechanical circulatory (MCS) support should be introduced to stabilize the systemic conditions and to connect to the next therapeutic stages. We conducted a clinical study (NCVC-BTD_01, National Cerebral and Cardiovascular Center-Bridge to Decision_01) to assess the safety and effectiveness of the novel developed extracorporeal continuous-flow ventricular assist system employing a disposable a...
Biventricular assist device (BVAD) implantation is the treatment of choice in patients with severe biventricular heart failure (BHF) and cardiogenic shock. We previously developed a miniaturized continuous flow double-ended centrifugal pump intended for total artificial heart implant (CFTAH). The purpose of this initial in vitro study was to prove that scaled down CFTAH can be suitable for biventricular support.
This study exams safety and efficacy of ambulatory inotropes as bridge to LVAD or transplant or pending evaluation for these therapies.
The utility of the intra-aortic balloon pump (IABP) in cardiogenic shock is debated in the heart failure (HF) community. We analyzed the nationwide usage and outcomes of IABP in patients admitted for HF exacerbation who required inotropic support, as well as the hospital cost incurred.
We report our institutional experience with the Impella 5.0 as a means to improve survival and serve as a bridge to clinical decision making in patients presenting with cardiogenic shock and severely decompensated end stage heart failure (HF).
The Model of End-Stage Liver Disease (MELD) score incorporates measures of kidney and liver dysfunction. MELD score has been shown to predict mortality in patients with advanced heart failure or cardiogenic shock (CS). Prior small single-center studies have shown that MELD score predicts mortality in patients supported with Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). The Purpose of our was to reassess the role of MELD score predicting Mortality After (VA-ECMO).
While intra-aortic balloon pump (IABP) counterpulsation has not been shown to be of benefit in patients with acute myocardial infarction (AMI) with cardiogenic shock (CS), emerging data suggest that patients with acute decompensated heart failure (ADHF) might be more likely to stabilize with this device.