Pharmacogenetic Variants in MTHFR Gene are Significant Predictors of Methotrexate Toxicities in Bangladeshi Acute Lymphoblastic Leukemia Patients

The present study investigated the effect of MTHFR C677T and A1298C polymorphisms on methotrexate (MTX) induced toxicities and increased plasma homocysteine level in Acute Lymphoblastic Leukemia (ALL) patients for the first time in Bangladesh. MTX induced mucositis and diarrhea are found to be significantly associated with MTHFR C677T and MTHFR A1298C polymorphisms. In addition, the risk of elevated plasma homocysteine level was 5 to 6 times higher for both polymorphisms.

Source: Clinical Lymphoma, Myeloma and Leukemia - December 3, 2019 Category: Hematology Authors: Fatema Tuz Zahra, Noor Ahmed Nahid, Md. Reazul Islam, Mir Md. Abdullah Al-Mamun, Mohd Nazmul Hasan Apu, Zabun Nahar, Amin Lutful kabir, Subrata K. Biswas, Maizbha Uddin Ahmed, Mohammad Safiqul Islam, Abul Hasnat Tags: Original Study Source Type: research