Therapy-Induced Changes in CXCR4 Expression in Tumor Xenografts Can Be Monitored Noninvasively with N- 11 CMethyl-AMD3465 PET

AbstractPurposeChemokine CXCL12 and its receptor CXCR4 are constitutively overexpressed in human cancers. The CXCL12-CXCR4 signaling axis plays an important role in tumor progression and metastasis, but also in treatment-induced recruitment of CXCR4-expressing cytotoxic immune cells. Here, we aimed to demonstrate the feasibility of N-[11C]methyl-AMD3465 positron emission tomography (PET) to monitor changes in CXCR4 density in tumors after single-fraction local radiotherapy or in combination with immunization.ProcedureTC-1 cells expressing human papillomavirus antigens E6 and E7 were inoculated into the C57BL/6 mice subcutaneously. Two weeks after tumor cell inoculation, mice were irradiated with a single-fraction 14-Gy dose of X-ray. One group of irradiated mice was immunized with an alpha-viral vector vaccine, SFVeE6,7, and another group received daily injections of the CXCR4 antagonist AMD3100 (3 mg/kg -intraperitoneal (i.p.)). Seven days after irradiation, all animals underwent N-[11C]methyl-AMD3465 PET.ResultsPET imaging showed N-[11C]methyl-AMD3465 uptake in the tumor of single-fraction irradiated mice was nearly 2.5-fold higher than in sham-irradiated tumors (1.07 ± 0.31 %ID/g vs. 0.42 ± 0.05 % ID/g,p
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research

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Although UV light is the main cause of skin cancers, beta human papillomavirus ( β-HPV) has been associated with squamous cell carcinoma risk, especially in immunocompromised patients such as transplant recipients. To probe this relationship in more detail, Strickley et al. investigated the role of these commensal viruses in skin cancer in a mouse papillomavirus type 1 infecti on system. Infected wild-type immunocompetent mice exhibited a delay in skin tumor onset and developed fewer tumors overall in response to either chemical or UVR exposure.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research
Human papillomavirus (HPV)-induced cervical cancer is a major health issue among women from the poorly/under-developed sectors of the world. It accounts for a high-mortality rate because of its late diagnosis and poor prognosis. Initial establishment and subsequent progression of this form of cancer are completely dependent on two major oncogenes E6 and E7, which are expressed constitutively leading to tumorigenesis. Thus, manipulation of these genes represents the most successful form of cervical cancer therapy. In the present article, information on structural, functional, and clinical dimensions of E6 and E7 activity ha...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
A new detection method rolled out last month looks for traces of the human papillomavirus (HPV), which cause nearly all cervical tumours.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CERVICAL cancer could be ­eliminated thanks to an improved screening method, health chiefs have revealed. In the past, screening samples have been examined and those that showed possible cell changes tested for the human papillomavirus viral infection, that causes the cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
s Joe S. Mymryk Human papillomavirus (HPV) causes an increasing number of head and neck squamous cell carcinomas (HNSCCs). Altered metabolism contributes to patient prognosis, but the impact of HPV status on HNSCC metabolism remains relatively uncharacterized. We hypothesize that metabolism-related gene expression differences unique to HPV-positive HNSCC influences patient survival. The Cancer Genome Atlas RNA-seq data from primary HNSCC patient samples were categorized as 73 HPV-positive, 442 HPV-negative, and 43 normal-adjacent control tissues. We analyzed 229 metabolic genes and identified numerous differentially ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
To the Editor We read with interest the report by Masroor et al, suggesting that among patients with human papillomavirus (HPV)-associated oropharyngeal cancers, National Comprehensive Cancer Network (NCCN)-recommended regular posttreatment clinical examinations did not detect recurrence or improve survival, compared with observation. Among the 22 of 233 study patients who had recurrent disease, the authors report that 10 were symptom directed and 11 were imaging detected, indicating that half of all recurrences were detected by imaging, which contradicts the NCCN ’s statement that most recurrences are reported by th...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
Short-term mortality among patients with oropharynx cancer (OPC) is lower when the cancer is positive for the human papillomavirus (HPV), a review of data finds.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
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Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
People with a type of throat cancer caused by human papillomavirus appear to have a better chance at surviving the disease than those with other types of tumors, a new study has found.
Source: Health News - - Category: Consumer Health News Source Type: news
MONDAY, Jan. 13, 2020 -- For patients with oropharynx cancer, the rates of head and neck cancer (HNC) mortality and competing mortality vary depending on human papillomavirus (HPV) status, with increased risks for HNC mortality and competing...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
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