Preeclampsia exposed offspring have greater body mass index than non-exposed offspring during peripubertal life: A meta-analysis
This study evaluates the effect of preeclampsia on body mass index (BMI) of offspring who were exposed to preeclampsia in utero.MethodsData were obtained from studies identified by a literature search in electronic databases. Random-effects metanalyses were conducted to achieve mean difference in BMI, waist circumference, gestation length, and birthweight between preeclampsia exposed (PE) and non-exposed (non-PE) offspring older than 5 years. Metaregression analyses were performed to identify factors affecting offspring BMI.ResultsSixteen studies (11639 PE offspring; age 15.5 years [14.2, 16.8]; 33.3% [32.6, 33.9] males vs 526,576 non-PE offspring; age 15.7 years [15.0, 16.4]; 42.6% [40.6, 44.5] male) were used. Gestation duration and birthweight of PE fetuses were significantly lesser than those of non-PE fetuses (mean difference (MD) −0.66 weeks [−1.25, −0.07]; p = 0.03 and MD −207.9 [−344.0, −71.8]; p = 0.003) respectively. BMI of PE offspring was significantly higher than non-PE offspring (MD 0.54 kg/m2 [0.27, 0.82]; p = 0.0001). Odds of being obese was significantly higher in PE than non-PE offspring (odds ratio 2.12 [1.70, 2.66]; P
The objective of this study was to estimate the risk of perinatal complications among MHO women compared to normal weight women.
In the past three decades, the incidence of preeclampsia, characterized by hypertension, proteinuria and end organ damage, has significantly increased in the U.S., in association with an increase in maternal weight. There is a gap in our understanding regarding how obesity influences preeclampsia. Ankiryn-repeat-and-SOCS-box-containing-protein 4 (ASB4) contributes to the differentiation of trophoblast stem cells into the giant trophoblast cells necessary for embryo implantation in mice. ASB4-null females develop preeclampsia-like phenotypes during pregnancy.
In this study, the impact of prenatal infection (PNI), using a naturally occurring rodent pathogen, Mycoplasma pulmonis (MP), on adult body weight and cardiovascular function was evaluated. Pregnant Sprague Dawley rats were infected with MP on gestational day 14 and gave birth naturally. Adult PNI offspring of weighed more than controls, but resting mean arterial pressure (MAP) was unchanged. Subcutaneous injection of angiotensin II (Ang II; 10 μg/kg) elicited a rise in MAP that was greater in both male and female PNI offspring compared to controls (P
Right now, one in 12 children and adolescents in the US are severely obese. If that isn’t startling enough, consider this: among 12-to-15-year-olds, that number jumps to one in 10 — and among 16-to-19-year-olds, it is one in seven. According to the American Academy of Pediatrics (AAP), the best hope for many of these youths may be bariatric surgery. Bariatric surgery is surgery that helps with weight loss by making the stomach smaller and making other changes in the digestive system. It’s jarring to think about doing irreversible surgery on an adolescent — or a child, as the AAP discourages age limi...
(Reuters Health) - Obese women who have weight-loss surgery between pregnancies may be less likely to experience complications like high blood pressure and preterm births in their second pregnancy, a recent study suggests.
Conclusion(s)Childhood adiposity was associated with increased risk of pregnancy hypertension, with the association of childhood abdominal obesity independent of adult abdominal obesity. Women who were persistently overweight/obese or abdominally obese since childhood had the highest risk of pregnancy hypertension.
Worldwide, hypertension (high blood pressure) and complications that stem from it are the second leading cause of maternal mortality. In fact, it causes about one in six maternal deaths. Among pregnant women in the US, rates of both chronic high blood pressure and pregnancy-related high blood pressure are rising. One reason this is worrisome is that high blood pressure is a major factor in preeclampsia, a potentially life-threatening condition that may affect women late in pregnancy and in the early weeks after birth. Now a study in Obstetrics and Gynecology suggests that a team approach to monitoring blood pressure at hom...
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Publication date: Available online 1 October 2019Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Claudia Nieto, Lizbeth Tolentino-Mayo, Eric Monterrubio-Flores, Catalina Medina, Sofia Rincón-Gallardo Patiño, Rebeca Aguirre-Hernández, Simón BarqueraAbstractBackgroundNon-communicable diseases, such as obesity, diabetes, and hypertension, can be prevented and treated through a balanced nutrient-rich diet. Nutrition labels have been recognized as crucial to preventing obesity and non-communicable diseases through a healthier diet.ObjectiveOur aim was to examine the association be...
Conclusion: It was concluded that hypertension risk was positively associated with being overweight, obesity, age and consumption of salted meat.It was inter aliaemphasized that engagement in healthy eating with less consumption of salted meats, and more consumption of fruits would assist in controlling hypertension among Ghanaian women.